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Development of triaryl antimicrobials by scaffold hopping from an aminopropanol hit targeting bacterial RNA polymerase-NusG interactions.

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Title: Development of triaryl antimicrobials by scaffold hopping from an aminopropanol hit targeting bacterial RNA polymerase-NusG interactions.
Authors: Liu T; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China., Kan CH; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China., Zheng Y; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China., Tsang TF; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China., Liu Y; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China., Tsang MW; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China., Fang H; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China., Lam LY; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China., Yang X; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China., Ma C; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2543923. Date of Electronic Publication: 2025 Aug 18.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of triaryl antimicrobials by scaffold hopping from an aminopropanol hit targeting bacterial RNA polymerase-NusG interactions.
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  Data: <searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Kan+CH%22">Kan CH</searchLink>; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tsang+TF%22">Tsang TF</searchLink>; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tsang+MW%22">Tsang MW</searchLink>; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Fang+H%22">Fang H</searchLink>; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Lam+LY%22">Lam LY</searchLink>; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.; Marshall Research Centre for Medical Microbial Biotechnology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
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  Data: <searchLink fieldCode="JN" term="%22101150203%22">Journal of enzyme inhibition and medicinal chemistry</searchLink> [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2543923. <i>Date of Electronic Publication: </i>2025 Aug 18.
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        Value: 10.1080/14756366.2025.2543923
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              Text: 2025 Dec
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