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Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies.

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Title: Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies.
Authors: Roark RS; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons , New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University , New York, NY, USA.; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Vaccine and Immunotherapy Center, The Wistar Institute , Philadelphia, PA, USA., Gorman J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Connell AJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bonsignori M; Translational Immunobiology Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Guo Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons , New York, NY, USA., Hogarty MP; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Olia AS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Sowers KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhang B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bylund T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Callaghan S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Carey JW; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cerutti G; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University , New York, NY, USA., Harris DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., He W; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Lewis E; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Liu T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Mason RD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Qiao Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons , New York, NY, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rando JM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Singh A; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wolff JJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Lei QP; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Louder MK; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Doria-Rose NA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Saunders KO; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University School of Medicine , Durham, NC, USA.; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center , Boston, MA, USA., Haynes BF; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University School of Medicine , Durham, NC, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Kulp DW; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Vaccine and Immunotherapy Center, The Wistar Institute , Philadelphia, PA, USA., Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Pierson TC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Sheng Z; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons , New York, NY, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kwong PD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons , New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA., Shapiro L; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons , New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University , New York, NY, USA.
Source: The Journal of experimental medicine [J Exp Med] 2025 Oct 06; Vol. 222 (10). Date of Electronic Publication: 2025 Aug 18.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Roark+RS%22">Roark RS</searchLink>; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons , New York, NY, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University , New York, NY, USA.; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Habib+R%22">Habib R</searchLink>; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Vaccine and Immunotherapy Center, The Wistar Institute , Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gorman+J%22">Gorman J</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; 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