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JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer.

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Title: JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer.
Authors: Alexandrou S; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Lee CS; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Fernandez KJ; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Wiharja CE; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Eshraghi L; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Reeves J; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia., Reed DA; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Portman N; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Phan Z; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Milioli HH; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Nikolic I; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Cadell AL; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Croucher DR; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Simpson KJ; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC, Australia., Lim E; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Hickey TE; Dame Roma Mitchell Cancer Research Adelaide Medical School Laboratories, University of Adelaide, Adelaide, Australia., Millar EKA; Department of Anatomical Pathology, NSW Health Pathology, St George Hospital, Sydney, NSW, Australia.; St George & Sutherland Campus, School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia., Alves CL; Department of Molecular Medicine, Cancer Research Unit, University of Southern Denmark, Odense, Denmark., Ditzel HJ; Department of Molecular Medicine, Cancer Research Unit, University of Southern Denmark, Odense, Denmark.; Department of Oncology, Odense University Hospital, Odense, Denmark., Caldon CE; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia. l.caldon@garvan.org.au.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia. l.caldon@garvan.org.au.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2025 Aug 19; Vol. 44 (1), pp. 244. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Alexandrou+S%22">Alexandrou S</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+CS%22">Lee CS</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Fernandez+KJ%22">Fernandez KJ</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wiharja+CE%22">Wiharja CE</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Eshraghi+L%22">Eshraghi L</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Reeves+J%22">Reeves J</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Reed+DA%22">Reed DA</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Portman+N%22">Portman N</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Phan+Z%22">Phan Z</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Milioli+HH%22">Milioli HH</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Nikolic+I%22">Nikolic I</searchLink>; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cadell+AL%22">Cadell AL</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Croucher+DR%22">Croucher DR</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Simpson+KJ%22">Simpson KJ</searchLink>; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+E%22">Lim E</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hickey+TE%22">Hickey TE</searchLink>; Dame Roma Mitchell Cancer Research Adelaide Medical School Laboratories, University of Adelaide, Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Millar+EKA%22">Millar EKA</searchLink>; Department of Anatomical Pathology, NSW Health Pathology, St George Hospital, Sydney, NSW, Australia.; St George & Sutherland Campus, School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Alves+CL%22">Alves CL</searchLink>; Department of Molecular Medicine, Cancer Research Unit, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Ditzel+HJ%22">Ditzel HJ</searchLink>; Department of Molecular Medicine, Cancer Research Unit, University of Southern Denmark, Odense, Denmark.; Department of Oncology, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Caldon+CE%22">Caldon CE</searchLink>; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia. l.caldon@garvan.org.au.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia. l.caldon@garvan.org.au.
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  Data: <searchLink fieldCode="JN" term="%228308647%22">Journal of experimental & clinical cancer research : CR</searchLink> [J Exp Clin Cancer Res] 2025 Aug 19; Vol. 44 (1), pp. 244. <i>Date of Electronic Publication: </i>2025 Aug 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8308647 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-9966 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203929078%22">03929078 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Clin Cancer Res <i>Subsets: </i>MEDLINE
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