Assessing genotype-phenotype correlations in colorectal cancer with deep learning: a multicentre cohort study.

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Title: Assessing genotype-phenotype correlations in colorectal cancer with deep learning: a multicentre cohort study.
Authors: Gustav M; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., van Treeck M; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Reitsam NG; Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Carrero ZI; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Loeffler CML; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Rabasco Meneghetti A; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Märkl B; Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Boardman LA; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., French AJ; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Goode EL; Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA., Gsur A; Center for Cancer Research, Medical University of Vienna, Vienna, Austria., Brezina S; Center for Cancer Research, Medical University of Vienna, Vienna, Austria., Gunter MJ; Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, Lyon, France; Cancer Epidemiology and Prevention Research Unit, School of Public Health, Imperial College London, London, UK., Murphy N; Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, Lyon, France., Hönscheid P; Institute of Pathology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; National Center for Tumor Diseases, Partner Site Dresden, German Cancer Research Center Heidelberg, Dresden, Germany; German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany., Sperling C; Institute of Pathology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Foersch S; Institute of Pathology, University Medical Center Mainz, Mainz, Germany., Steinfelder R; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Harrison T; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Phipps A; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Kather JN; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany; Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. Electronic address: jakob-nikolas.kather@alumni.dkfz.de.
Source: The Lancet. Digital health [Lancet Digit Health] 2025 Aug; Vol. 7 (8), pp. 100891. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101751302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-7500 (Electronic) Linking ISSN: 25897500 NLM ISO Abbreviation: Lancet Digit Health Subsets: MEDLINE
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  Data: Assessing genotype-phenotype correlations in colorectal cancer with deep learning: a multicentre cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Gustav+M%22">Gustav M</searchLink>; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22van+Treeck+M%22">van Treeck M</searchLink>; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Reitsam+NG%22">Reitsam NG</searchLink>; Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Carrero+ZI%22">Carrero ZI</searchLink>; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Loeffler+CML%22">Loeffler CML</searchLink>; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Rabasco+Meneghetti+A%22">Rabasco Meneghetti A</searchLink>; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Märkl+B%22">Märkl B</searchLink>; Pathology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Boardman+LA%22">Boardman LA</searchLink>; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22French+AJ%22">French AJ</searchLink>; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Goode+EL%22">Goode EL</searchLink>; Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Gsur+A%22">Gsur A</searchLink>; Center for Cancer Research, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brezina+S%22">Brezina S</searchLink>; Center for Cancer Research, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gunter+MJ%22">Gunter MJ</searchLink>; Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, Lyon, France; Cancer Epidemiology and Prevention Research Unit, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+N%22">Murphy N</searchLink>; Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Hönscheid+P%22">Hönscheid P</searchLink>; Institute of Pathology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; National Center for Tumor Diseases, Partner Site Dresden, German Cancer Research Center Heidelberg, Dresden, Germany; German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sperling+C%22">Sperling C</searchLink>; Institute of Pathology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Foersch+S%22">Foersch S</searchLink>; Institute of Pathology, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Steinfelder+R%22">Steinfelder R</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Harrison+T%22">Harrison T</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Peters+U%22">Peters U</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Phipps+A%22">Phipps A</searchLink>; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kather+JN%22">Kather JN</searchLink>; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany; Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany; Pathology and Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. Electronic address: jakob-nikolas.kather@alumni.dkfz.de.
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