Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma.

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Title: Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma.
Authors: Nassar AH; Department of Medicine (Medical Oncology), Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA., Kim C; Division of Hematology and Oncology, Georgetown Cancer Institute, Washington, DC, USA., Adeyelu T; Caris Life Sciences, Phoenix, AZ, USA., Bou Farhat E; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, USA., Abushukair H; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Rakaee M; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway., Matteson K; Department of Medicine (Medical Oncology), Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA., Lau SF; Department of Immunobiology, Yale University, New Haven, CT, USA., Takabe Y; Department of Immunobiology, Yale University, New Haven, CT, USA., Ocejo A; Division of Medical Oncology, Jackson Memorial Hospital, Miami, FL, USA., Ardeshir-Larijani F; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Leal T; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Ramalingam S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Alam S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA., Gray JE; Division of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL, USA., Hicks J; Division of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL, USA., Kaldas D; Division of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL, USA., Baena J; Department of Medical Oncology, Hospital 12 de Octubre, Madrid, Spain., Berjaga MZ; Department of Medical Oncology, Hospital 12 de Octubre, Madrid, Spain., Nana FA; Division of Pneumology, Cliniques Universitaires Saint Luc, Bruxelles, Belgium., Grohe C; Klinik für Pneumologie-Evangelische Lungenklinik, Berlin Buch, Berlin, Germany., Leuders H; Klinik für Pneumologie-Evangelische Lungenklinik, Berlin Buch, Berlin, Germany., Citarella F; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Cortellini A; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.; Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK., Mingo EC; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy., Pancirer D; Department of Medicine, Stanford Cancer Institute, Stanford, CA, USA., Das M; Department of Medicine, Stanford Cancer Institute, Stanford, CA, USA.; Department of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, USA., Ellis-Caleo TJ; Department of Medicine, Stanford Cancer Institute, Stanford, CA, USA., Cheung JM; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Lin JJ; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Watson AS; Division of Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA., Camidge DR; Division of Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA., Sridhar A; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Parikh K; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Crowley F; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marron TU; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Aggarwal V; Division of Hematology and Oncology, Georgetown Cancer Institute, Washington, DC, USA., Ahmed M; Division of Medical Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Sankar K; Division of Medical Oncology, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA., Kawtharany H; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA., Zhang J; Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA., Owen DH; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Li M; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Nagasaka M; Department of Medicine, UC Irvine, Irvine, CA, USA., Pinato DJ; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Division of Oncology, Department of Translational Medicine (DIMET), University of Piemonte Orientale, Novara, Italy., Awosika N; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK., Alhamad K; Division of Medical Oncology, Huntsman Cancer Institute, Salt Lake City, UT, USA., Puri S; Division of Medical Oncology, Huntsman Cancer Institute, Salt Lake City, UT, USA., Zaman U; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Gupta DM; Division of Medical Oncology, Northwestern University, Chicago, IL, USA., Lau C; Division of Medical Oncology, Northwestern University, Chicago, IL, USA., Khan H; Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, Providence, RI, USA., Liauw J; Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, Providence, RI, USA., Velazquez AI; Division of Medical Oncology, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA., Brown T; Division of Medical Oncology, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA., Moliner L; Division of Medical Oncology, Institut Catala d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain., Mosteiro M; Division of Medical Oncology, Institut Catala d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain., Rocha P; Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Evans M; Caris Life Sciences, Phoenix, AZ, USA., Vanderwalde A; Caris Life Sciences, Phoenix, AZ, USA., Elliott A; Caris Life Sciences, Phoenix, AZ, USA., Nieva J; Division of Medical Oncology, Norris Cancer Center, University of Southern California, Los Angeles, CA, USA., Lopes G; Division of Medical Oncology, Jackson Memorial Hospital, Miami, FL, USA., Ma PC; Penn State Cancer Institute, Penn State Health Milton S. Hershey Medical Center, Penn State College of Medicine, Penn State University, Hershey, PA, USA., Borghaei H; Department of Hematology and Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA., Lee M; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY, USA., Young L; Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY, USA., Aljumaily R; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Mirza H; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Kwiatkowski DJ; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, USA., Herbst RS; Department of Medicine (Medical Oncology), Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA., Flavell RA; Department of Immunobiology, Yale University, New Haven, CT, USA., Naqash AR; Division of Medical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. abdulrafeh-naqash@ou.edu., Chiang AC; Department of Medicine (Medical Oncology), Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA. anne.chiang@yale.edu.
Source: Nature communications [Nat Commun] 2025 Aug 19; Vol. 16 (1), pp. 7717. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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      – PersonEntity:
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            NameFull: Aljumaily R
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            NameFull: Mirza H
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          Dates:
            – D: 19
              M: 08
              Text: 2025 Aug 19
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1