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Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

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Title: Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.
Authors: de Weerd L; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. lis.deweerd@dzne.de., Hummel S; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Müller SA; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Paris I; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Sandmann T; Denali Therapeutics, Inc, South San Francisco, USA., Eichholtz M; Biochemistry Master's Program, Gene Center Munich, Ludwig-Maximilians University (LMU), Munich, Germany., Gröger R; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Englert AL; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Wagner S; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany., Ha C; Denali Therapeutics, Inc, South San Francisco, USA., Davis SS; Denali Therapeutics, Inc, South San Francisco, USA., Warkins V; Denali Therapeutics, Inc, South San Francisco, USA., Xia D; Denali Therapeutics, Inc, South San Francisco, USA., Nuscher B; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany., Berghofer A; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Reich M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Feiten AF; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany., Schlepckow K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Willem M; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Lewcock JW; Denali Therapeutics, Inc, South San Francisco, USA., Monroe KM; Denali Therapeutics, Inc, South San Francisco, USA., Brendel M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Haass C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.
Source: Molecular neurodegeneration [Mol Neurodegener] 2025 Aug 20; Vol. 20 (1), pp. 92. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.
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  Data: <searchLink fieldCode="AU" term="%22de+Weerd+L%22">de Weerd L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. lis.deweerd@dzne.de.<br /><searchLink fieldCode="AU" term="%22Hummel+S%22">Hummel S</searchLink>; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+SA%22">Müller SA</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Paris+I%22">Paris I</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sandmann+T%22">Sandmann T</searchLink>; Denali Therapeutics, Inc, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Eichholtz+M%22">Eichholtz M</searchLink>; Biochemistry Master's Program, Gene Center Munich, Ludwig-Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gröger+R%22">Gröger R</searchLink>; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Englert+AL%22">Englert AL</searchLink>; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+S%22">Wagner S</searchLink>; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ha+C%22">Ha C</searchLink>; Denali Therapeutics, Inc, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Davis+SS%22">Davis SS</searchLink>; Denali Therapeutics, Inc, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Warkins+V%22">Warkins V</searchLink>; Denali Therapeutics, Inc, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Xia+D%22">Xia D</searchLink>; Denali Therapeutics, Inc, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Nuscher+B%22">Nuscher B</searchLink>; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Berghofer+A%22">Berghofer A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Reich+M%22">Reich M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Feiten+AF%22">Feiten AF</searchLink>; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schlepckow+K%22">Schlepckow K</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Willem+M%22">Willem M</searchLink>; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lichtenthaler+SF%22">Lichtenthaler SF</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lewcock+JW%22">Lewcock JW</searchLink>; Denali Therapeutics, Inc, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Monroe+KM%22">Monroe KM</searchLink>; Denali Therapeutics, Inc, South San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Brendel+M%22">Brendel M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Nuclear Medicine, University Hospital of Munich, Ludwig- Maximilians University (LMU), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Haass+C%22">Haass C</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.; Metabolic Biochemistry, Biomedical Center, Faculty of Medicine, Ludwig- Maximilians University (LMU), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. christian.haass@mail03.med.uni-muenchen.de.
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  Data: <searchLink fieldCode="JN" term="%22101266600%22">Molecular neurodegeneration</searchLink> [Mol Neurodegener] 2025 Aug 20; Vol. 20 (1), pp. 92. <i>Date of Electronic Publication: </i>2025 Aug 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101266600 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-1326 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217501326%22">17501326 </searchLink><i>NLM ISO Abbreviation: </i>Mol Neurodegener <i>Subsets: </i>MEDLINE
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