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Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.

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Title: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.
Authors: Shen X; Division of Psychiatry, University of Edinburgh, Edinburgh, UK. Xueyi.shen@ed.ac.uk., Toenders YJ; Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands., Han LKM; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Orygen, Parkville, VIC, Australia.; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Weihs A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Germany., Alexander N; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Andlauer TFM; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Brosch K; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.; Centre for Human Genetics, Philipps-University Marburg, Marburg, Germany., Grotegerd D; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Hermesdorf M; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Hosten N; Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Jamalabadi H; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Meinert S; Institute for Translational Psychiatry, University of Münster, Münster, Germany.; Institute for Translational Neuroscience, University of Münster, Münster, Germany., Milaneschi Y; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Complex Trait Genetics, Amsterdam, The Netherlands., Sämann PG; Max Planck Institute of Psychiatry, Munich, Germany., Stein F; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Stolicyn A; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Teutenberg L; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Thng G; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Adams MJ; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Thomas-Odenthal F; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Usemann P; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Völker U; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Herrera-Rivero M; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Jiang Y; 23andMe, San Francisco, CA, USA., Tian C; 23andMe, San Francisco, CA, USA., Groenewold NA; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Koopowitz SM; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Strike LT; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Jansen A; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Nenadić I; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Sim K; West Region, Institute of Mental Health, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Straube B; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Stein DJ; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.; SAMRC Research Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Krug A; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., McMahon KL; School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., de Zubicaray G; School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia., Pozzi E; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Orygen, Parkville, VIC, Australia., Veltman DJ; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Schmaal L; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.; Orygen, Parkville, VIC, Australia., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Whalley HC; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Corporate Authors: 23andMe Research Team, ENIGMA MDD working group
Source: Molecular psychiatry [Mol Psychiatry] 2026 Feb; Vol. 31 (2), pp. 611-621. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-5578
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Molecular psychiatry
              Type: main
ResultId 1