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Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment.

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Title: Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment.
Authors: Remesal L; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA. lauraremesalgomez@gmail.com., Sucharov-Costa J; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Wu Y; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA., Pratt KJB; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Bieri G; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA., Philp A; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA., Phan M; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA., Aghayev T; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA., White CW 3rd; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Wheatley EG; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Zou B; AfaSci Research Laboratory, Redwood City, CA, USA., Desousa BR; Department of Biochemistry, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA., Couthouis J; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Jian IH; Department of Biochemistry, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA., Xie XS; AfaSci Research Laboratory, Redwood City, CA, USA., Lu Y; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA., Maynard JC; Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Burlingame AL; Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Villeda SA; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Bakar Aging Research Institute, San Francisco, CA, USA. saul.villeda@ucsf.edu.
Source: Nature aging [Nat Aging] 2025 Oct; Vol. 5 (10), pp. 1957-1969. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment.
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  Data: <searchLink fieldCode="AU" term="%22Remesal+L%22">Remesal L</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA. lauraremesalgomez@gmail.com.<br /><searchLink fieldCode="AU" term="%22Sucharov-Costa+J%22">Sucharov-Costa J</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Pratt+KJB%22">Pratt KJB</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bieri+G%22">Bieri G</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Philp+A%22">Philp A</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Phan+M%22">Phan M</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Aghayev+T%22">Aghayev T</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22White+CW+3rd%22">White CW 3rd</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wheatley+EG%22">Wheatley EG</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zou+B%22">Zou B</searchLink>; AfaSci Research Laboratory, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Desousa+BR%22">Desousa BR</searchLink>; Department of Biochemistry, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Couthouis+J%22">Couthouis J</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jian+IH%22">Jian IH</searchLink>; Department of Biochemistry, University of California, San Francisco, San Francisco, CA, USA.; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xie+XS%22">Xie XS</searchLink>; AfaSci Research Laboratory, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Maynard+JC%22">Maynard JC</searchLink>; Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Burlingame+AL%22">Burlingame AL</searchLink>; Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Villeda+SA%22">Villeda SA</searchLink>; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.; Bakar Aging Research Institute, San Francisco, CA, USA. saul.villeda@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2025 Oct; Vol. 5 (10), pp. 1957-1969. <i>Date of Electronic Publication: </i>2025 Aug 19.
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