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Phase 1/2 study of H3B-6545 in women with locally advanced/metastatic estrogen receptor-positive, HER2-negative breast cancer.

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Title: Phase 1/2 study of H3B-6545 in women with locally advanced/metastatic estrogen receptor-positive, HER2-negative breast cancer.
Authors: Hamilton E; Breast Cancer Research Program, Sarah Cannon Research Institute, Nashville, TN, USA. erika.hamilton@scri.com.; Sarah Cannon Research Institute, 335 24th Avenue North, Suite 300, Nashville, TN, 37203, USA. erika.hamilton@scri.com., Pluard T; Koontz Center for Advanced Breast Cancer, Saint Luke's Cancer Institute, Kansas City, MO, USA., Wang JS; Hematology and Oncology, Florida Cancer Specialists/Sarah Cannon Research Institute, Sarasota, FL, USA., Morikawa A; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Johnston S; Breast Unit, Royal Marsden NHS Foundation Trust, London, UK., Dees EC; Department of Medicine, Division of Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA., Vaklavas C; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Armstrong A; Division of Cancer Studies, University of Manchester, Manchester, UK.; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK., Munster P; Division of Hematology and Oncology, University of California, San Francisco, CA, USA., Unni N; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Wright GS; Medical Oncology, Florida Cancer Specialists & Research Institute/Sarah Cannon Research Institute, Trinity, FL, USA., Kayali F; Hematology and Oncology, Florida Cancer Specialists, Lakewood Ranch/Sarasota, FL, USA., Song T; Eisai Inc, Nutley, NJ, USA., Rong Y; Eisai Inc, Nutley, NJ, USA., Yamaguchi K; Eisai Co., Ltd, Tokyo, Japan., Juric D; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Source: Breast cancer research : BCR [Breast Cancer Res] 2025 Aug 19; Vol. 27 (1), pp. 151. Date of Electronic Publication: 2025 Aug 19.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study; Clinical Trial, Phase I
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase 1/2 study of H3B-6545 in women with locally advanced/metastatic estrogen receptor-positive, HER2-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Hamilton+E%22">Hamilton E</searchLink>; Breast Cancer Research Program, Sarah Cannon Research Institute, Nashville, TN, USA. erika.hamilton@scri.com.; Sarah Cannon Research Institute, 335 24th Avenue North, Suite 300, Nashville, TN, 37203, USA. erika.hamilton@scri.com.<br /><searchLink fieldCode="AU" term="%22Pluard+T%22">Pluard T</searchLink>; Koontz Center for Advanced Breast Cancer, Saint Luke's Cancer Institute, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wang+JS%22">Wang JS</searchLink>; Hematology and Oncology, Florida Cancer Specialists/Sarah Cannon Research Institute, Sarasota, FL, USA.<br /><searchLink fieldCode="AU" term="%22Morikawa+A%22">Morikawa A</searchLink>; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Johnston+S%22">Johnston S</searchLink>; Breast Unit, Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Dees+EC%22">Dees EC</searchLink>; Department of Medicine, Division of Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Vaklavas+C%22">Vaklavas C</searchLink>; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Armstrong+A%22">Armstrong A</searchLink>; Division of Cancer Studies, University of Manchester, Manchester, UK.; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Munster+P%22">Munster P</searchLink>; Division of Hematology and Oncology, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Unni+N%22">Unni N</searchLink>; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wright+GS%22">Wright GS</searchLink>; Medical Oncology, Florida Cancer Specialists & Research Institute/Sarah Cannon Research Institute, Trinity, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kayali+F%22">Kayali F</searchLink>; Hematology and Oncology, Florida Cancer Specialists, Lakewood Ranch/Sarasota, FL, USA.<br /><searchLink fieldCode="AU" term="%22Song+T%22">Song T</searchLink>; Eisai Inc, Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Rong+Y%22">Rong Y</searchLink>; Eisai Inc, Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+K%22">Yamaguchi K</searchLink>; Eisai Co., Ltd, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Juric+D%22">Juric D</searchLink>; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%22100927353%22">Breast cancer research : BCR</searchLink> [Breast Cancer Res] 2025 Aug 19; Vol. 27 (1), pp. 151. <i>Date of Electronic Publication: </i>2025 Aug 19.
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  Data: Journal Article; Clinical Trial, Phase II; Multicenter Study; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100927353 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1465-542X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214655411%22">14655411 </searchLink><i>NLM ISO Abbreviation: </i>Breast Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13058-025-02069-8
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              Text: 2025 Aug 19
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