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The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.

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Title: The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.
Authors: Cole AR; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Buj R; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Uboveja A; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Levasseur E; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Wang H; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Kedziora KM; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA., Chatoff A; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA., Huacachino AA; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA., Marcinkiewicz MM; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA., Amalric A; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Yang B; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Tsinghua University School of Medicine, Beijing, P.R. China., Tangudu NK; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Danielson J; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Elwah A; Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA., White S; Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA., Li D; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA., Wallace CT; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA., Lazure F; Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL., Elishaev E; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Borho L; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA., Jazwinska DE; Department of Bioengineering and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA., Laird MS; Department of Bioengineering and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA., Atiya H; Division of Malignant Hematology & Medical Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Bitler BG; Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO., Dangaj D; Ludwig Institute for Cancer Research, University of Lausanne (UNIL), Lausanne, Switzerland., Coffman LG; Division of Malignant Hematology & Medical Oncology, Department of Medicine, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Tseng G; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA., Oesterreich S; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA., Gomes AP; Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL., Gurkar AU; Aging Institute of UPMC and the Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA., Schopfer FJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, U.S.A; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute (VMI); Pittsburgh Liver Research Center (PLRC); and Center for Immunometabolism, Pittsburgh, PA., Modugno F; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Watkins SC; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA., Zervantonakis IK; Department of Bioengineering and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA., Stallaert W; Department of Computational and Systems Biology, UPMC Hillman Cancer Center, University of Pittsburgh, PA., Hempel N; Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA., Snyder NW; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA., Aird KM; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Aug 12. Date of Electronic Publication: 2025 Aug 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.
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Lee Moffitt Cancer Center & Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Gurkar+AU%22">Gurkar AU</searchLink>; Aging Institute of UPMC and the Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Schopfer+FJ%22">Schopfer FJ</searchLink>; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, U.S.A; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute (VMI); Pittsburgh Liver Research Center (PLRC); and Center for Immunometabolism, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Modugno+F%22">Modugno F</searchLink>; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Watkins+SC%22">Watkins SC</searchLink>; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Zervantonakis+IK%22">Zervantonakis IK</searchLink>; Department of Bioengineering and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Stallaert+W%22">Stallaert W</searchLink>; Department of Computational and Systems Biology, UPMC Hillman Cancer Center, University of Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Hempel+N%22">Hempel N</searchLink>; Department of Medicine and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Snyder+NW%22">Snyder NW</searchLink>; Aging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Aird+KM%22">Aird KM</searchLink>; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA.
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