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EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.

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Title: EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Authors: German B; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Morel KL; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia., Noel T; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA., Boufaied N; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada., Burkhart DL; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Chen S; West China School of Public Health, West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China., Dezem F; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA., Qui X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Long HW; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., DiFazio S; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Baca S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Shafi AA; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Freedman ML; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Beltran H; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Sweeney CJ; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Brown M; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Plummer JT; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA., Knott SRV; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles CA, USA., Labbe DP; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada., Ellis L; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Aug 11. Date of Electronic Publication: 2025 Aug 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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  Data: EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
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  Data: <searchLink fieldCode="AU" term="%22German+B%22">German B</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Morel+KL%22">Morel KL</searchLink>; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia.<br /><searchLink fieldCode="AU" term="%22Noel+T%22">Noel T</searchLink>; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA.<br /><searchLink fieldCode="AU" term="%22Boufaied+N%22">Boufaied N</searchLink>; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Burkhart+DL%22">Burkhart DL</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; West China School of Public Health, West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Dezem+F%22">Dezem F</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA.<br /><searchLink fieldCode="AU" term="%22Qui+X%22">Qui X</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Long+HW%22">Long HW</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22DiFazio+S%22">DiFazio S</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Baca+S%22">Baca S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Shafi+AA%22">Shafi AA</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Freedman+ML%22">Freedman ML</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Beltran+H%22">Beltran H</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Sweeney+CJ%22">Sweeney CJ</searchLink>; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia.<br /><searchLink fieldCode="AU" term="%22He+HH%22">He HH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Brown+M%22">Brown M</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Plummer+JT%22">Plummer JT</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA.<br /><searchLink fieldCode="AU" term="%22Knott+SRV%22">Knott SRV</searchLink>; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles CA, USA.<br /><searchLink fieldCode="AU" term="%22Labbe+DP%22">Labbe DP</searchLink>; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ellis+L%22">Ellis L</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
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