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ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African-ancestry populations.

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Title: ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African-ancestry populations.
Authors: Akgun B; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Gulyayev AV; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Coker M; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Olalusi O; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Neurology, University College Hospital, Ibadan, Nigeria., Adams LD; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Akinwande K; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Whitehead PG; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Diala S; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ogunronbi M; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Laux RA; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Akpalu A; Department of Medicine, University of Ghana Medical School/Korle Bu Teaching Hospital, Accra, Ghana., Starks TD; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Sarfo FS; Department of Medicine, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana., Chavez J; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA., Lwere K; Makerere University College of Health Sciences, Kampala, Uganda., Beecham GW; Department of Biostatistics and Data Science, Wake Forest School University of Medicine, Winston-Salem, North Carolina, USA., Akinyemi JO; Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria., Obiako R; Department of Medicine, Ahmadu Bello University, Zaria, Nigeria., Ndetei D; Africa Mental Health Research and Training Foundation/Department of Psychiatry, University of Nairobi, Nairobi, Kenya., Caban-Holt A; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Ayele B; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia., Ogrocki P; Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.; Department of Neurology, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA., Griswold AJ; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Zaman AF; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Mena PR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Martinez IM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA., Blanton SH; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Okubadejo N; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria., Damasceno A; Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique., Kalaria R; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., McInerney KF; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Bush WS; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Cleveland Institute for Computational Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Ogunniyi A; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Neurology, University College Hospital, Ibadan, Nigeria., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Akinyemi RO; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research & Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Department of Neurology, University College Hospital, Ibadan, Nigeria., Haines JL; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Cleveland Institute for Computational Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Reitz C; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA., Byrd GS; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Rajabli F; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Corporate Authors: African Dementia Consortium (AfDC), Alzheimer's Disease Sequencing Project (ADSP)
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Aug; Vol. 21 (8), pp. e70583.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African-ancestry populations.
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