TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation.
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| Title: | TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation. |
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| Authors: | Tuomela K; Department of Surgery, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada., Garcia RV; Department of Surgery, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada., Boardman DA; Department of Surgery, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada., Tavakoli P; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Ancheta-Schmit M; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Sham HP; BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Cheng L; Discovery Immunology, Bristol-Myers Squibb, Princeton, NJ, USA., Struthers M; Discovery Immunology, Bristol-Myers Squibb, Princeton, NJ, USA., Bressler B; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Vallance BA; BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Zhao Q; Discovery Immunology, Bristol-Myers Squibb, Princeton, NJ, USA., Levings MK; Department of Surgery, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada. Electronic address: mlevings@bcchr.ca. |
| Source: | Cell reports. Medicine [Cell Rep Med] 2025 Sep 16; Vol. 6 (9), pp. 102303. Date of Electronic Publication: 2025 Aug 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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