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Class I histone deacetylases catalyze lysine lactylation.

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Title: Class I histone deacetylases catalyze lysine lactylation.
Authors: Gonzatti MB; Department of Physiology, University of California, San Francisco, San Francisco, California, USA., Hintzen JCJ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sharma I; Department of Physiology, University of California, San Francisco, San Francisco, California, USA., Najar MA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Tsusaka T; Department of Physiology, University of California, San Francisco, San Francisco, California, USA., Marcinkiewicz MM; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Da Silva Crispim CV; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Snyder NW; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Burslem GM; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: George.Burslem@pennmedicine.upenn.edu., Goldberg EL; Department of Physiology, University of California, San Francisco, San Francisco, California, USA; Chan-Zuckerberg Biohub, San Francisco, California, USA. Electronic address: Emily.goldberg@ucsf.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110602. Date of Electronic Publication: 2025 Aug 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Class I histone deacetylases catalyze lysine lactylation.
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  Data: <searchLink fieldCode="AU" term="%22Gonzatti+MB%22">Gonzatti MB</searchLink>; Department of Physiology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Hintzen+JCJ%22">Hintzen JCJ</searchLink>; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+I%22">Sharma I</searchLink>; Department of Physiology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Najar+MA%22">Najar MA</searchLink>; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Tsusaka+T%22">Tsusaka T</searchLink>; Department of Physiology, University of California, San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Marcinkiewicz+MM%22">Marcinkiewicz MM</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Da+Silva+Crispim+CV%22">Da Silva Crispim CV</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Snyder+NW%22">Snyder NW</searchLink>; Aging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Burslem+GM%22">Burslem GM</searchLink>; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: George.Burslem@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Goldberg+EL%22">Goldberg EL</searchLink>; Department of Physiology, University of California, San Francisco, San Francisco, California, USA; Chan-Zuckerberg Biohub, San Francisco, California, USA. Electronic address: Emily.goldberg@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110602. <i>Date of Electronic Publication: </i>2025 Aug 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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              Text: 2025 Oct
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