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Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy.

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Title: Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy.
Authors: Baruch EN; Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gleber-Netto FO; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nagarajan P; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rao X; Department of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Akhter S; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Eichwald T; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Xie T; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Balood M; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Adewale A; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Naara S; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sathishkumar HN; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Islam S; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., McCarthy W; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mattson BJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ferrarotto R; Department of Head and Neck Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wong MK; Department of Melanoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Davies MA; Department of Melanoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jindal S; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Basu S; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Roversi K; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Nikpoor AR; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Ahmadi M; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Ahmadi A; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Harwood C; Department of Dermatology, Royal London Hospital, Barts Health NHS Trust, London, UK.; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Leigh I; Department of Dermatology, Royal London Hospital, Barts Health NHS Trust, London, UK.; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK., Gong D; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts Institute of Technology, Cambridge, MA, USA., Tallón de Lara P; Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tao DL; Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Davidson TM; Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ajami NJ; Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Futreal A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rai K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kochat V; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Castillo M; Department of Biology and Biochemistry, University of Houston Sequencing and Gene Editing Core, University of Houston, Houston, TX, USA., Gunaratne P; Department of Biology and Biochemistry, University of Houston Sequencing and Gene Editing Core, University of Houston, Houston, TX, USA., Goepfert RP; Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hernandez SD; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khushalani NI; Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA., Wang J; Department of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jingwang@mdanderson.org., Watowich SS; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Calin GA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Migden MR; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yuan M; Translational Research Center, New York University College of Dentistry, New York, NY, USA.; Pain Research Center, Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA., Liu N; Translational Research Center, New York University College of Dentistry, New York, NY, USA.; Pain Research Center, Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA., Ye Y; Translational Research Center, New York University College of Dentistry, New York, NY, USA.; Pain Research Center, Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA., Hwang WL; Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vermeer PD; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD, USA., D'Silva NJ; Department of Periodontics and Oral Medicine, The University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, The University of Michigan, Ann Arbor, MI, USA., Bunimovich YL; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Yaniv D; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Burks JK; Department of Hematopoietic Biology & Malignancies, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gomez J; Department of Hematopoietic Biology & Malignancies, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dougherty PM; Department of Pain Medicine, Division of Anesthesiology, Critical Care, and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tsai KY; Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Kenneth.Tsai@moffitt.org.; Department of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Kenneth.Tsai@moffitt.org., Allison JP; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sharma P; James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wargo JA; Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Myers JN; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Talbot S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. sebas.talbot@gmail.com.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. sebas.talbot@gmail.com., Gross ND; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Ndgross@mdanderson.org., Amit M; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Moranamit@gmail.com.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Moranamit@gmail.com.; UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Moranamit@gmail.com.; Cancer Neuroscience Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Moranamit@gmail.com.
Source: Nature [Nature] 2025 Oct; Vol. 646 (8084), pp. 462-473. Date of Electronic Publication: 2025 Aug 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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            NameFull: Tallón de Lara P
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            NameFull: Tao DL
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            NameFull: Davidson TM
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      – PersonEntity:
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      – PersonEntity:
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            NameFull: Kochat V
      – PersonEntity:
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            NameFull: Castillo M
      – PersonEntity:
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            NameFull: Gunaratne P
      – PersonEntity:
          Name:
            NameFull: Goepfert RP
      – PersonEntity:
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            NameFull: Hernandez SD
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            NameFull: Khushalani NI
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            NameFull: Wang J
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      – PersonEntity:
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          Dates:
            – D: 01
              M: 10
              Text: 2025 Oct
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 646
            – Type: issue
              Value: 8084
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1