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Development of a physiologically based pharmacokinetic model of N,N-dimethyltryptamine, harmine, and their interactions from ayahuasca in rats and humans.

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Title: Development of a physiologically based pharmacokinetic model of N,N-dimethyltryptamine, harmine, and their interactions from ayahuasca in rats and humans.
Authors: Wittayakarn N; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand., Tan YM; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand., Choomalaiwong P; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand., Chen S; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand., Hoer D; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, United States., Thaoboonruang N; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand., Lohitnavy M; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2025 Nov 01; Vol. 208 (1), pp. 48-60.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of a physiologically based pharmacokinetic model of N,N-dimethyltryptamine, harmine, and their interactions from ayahuasca in rats and humans.
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  Data: <searchLink fieldCode="AU" term="%22Wittayakarn+N%22">Wittayakarn N</searchLink>; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Tan+YM%22">Tan YM</searchLink>; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Choomalaiwong+P%22">Choomalaiwong P</searchLink>; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Hoer+D%22">Hoer D</searchLink>; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, United States.<br /><searchLink fieldCode="AU" term="%22Thaoboonruang+N%22">Thaoboonruang N</searchLink>; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Lohitnavy+M%22">Lohitnavy M</searchLink>; Center of Excellence for Environmental Health & Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Pharmacokinetic Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
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  Data: <searchLink fieldCode="JN" term="%229805461%22">Toxicological sciences : an official journal of the Society of Toxicology</searchLink> [Toxicol Sci] 2025 Nov 01; Vol. 208 (1), pp. 48-60.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9805461 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0929 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210960929%22">10960929 </searchLink><i>NLM ISO Abbreviation: </i>Toxicol Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1093/toxsci/kfaf118
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              Text: 2025 Nov 01
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