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Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial.

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Title: Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial.
Authors: Drummond KJ; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia. kate.drummond@mh.org.au.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia. kate.drummond@mh.org.au., Spiteri M; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia., Cain SA; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia., Jones J; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia., Shaya S; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Topp M; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Lu T; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia., Tobler R; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia., Valkovic AL; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia., Moore Z; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Fatunla OE; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Kriel J; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Moffet JJD; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., McAlpine H; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia., Rosier M; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia., Guan H; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia., Dimou J; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia., Schadewaldt V; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia., Roberts-Thomson S; Department of Anatomical Pathology, Royal Melbourne Hospital, Melbourne, Victoria, Australia., McArdle D; Department of Medical Imaging, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Radiology, University of Melbourne, Melbourne, Victoria, Australia., Lui E; Department of Medical Imaging, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Radiology, University of Melbourne, Melbourne, Victoria, Australia., Voelker-Albert M; MoleQlar Analytics GmbH, Munich, Germany., di Sanzo S; MoleQlar Analytics GmbH, Munich, Germany., Nijagal B; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia., Narayana VK; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia., Mitchell CB; Department Clinical Pathology, MDHS, University of Melbourne, Melbourne, Victoria, Australia.; Collaborative Centre for Genomic Cancer Medicine, MDHS, University of Melbourne, Melbourne, Victoria, Australia., Vissers JHA; Department Clinical Pathology, MDHS, University of Melbourne, Melbourne, Victoria, Australia.; Collaborative Centre for Genomic Cancer Medicine, MDHS, University of Melbourne, Melbourne, Victoria, Australia., Grimmond S; Collaborative Centre for Genomic Cancer Medicine, MDHS, University of Melbourne, Melbourne, Victoria, Australia., Rosenthal MA; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Palmer LM; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia., Best SA; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Freytag S; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Whittle JR; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia. whittle.j@wehi.edu.au.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. whittle.j@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia. whittle.j@wehi.edu.au.
Source: Nature medicine [Nat Med] 2025 Oct; Vol. 31 (10), pp. 3451-3463. Date of Electronic Publication: 2025 Aug 21.
Publication Type: Clinical Trial, Phase I; Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial.
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  Data: <searchLink fieldCode="AU" term="%22Drummond+KJ%22">Drummond KJ</searchLink>; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia. kate.drummond@mh.org.au.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia. kate.drummond@mh.org.au.<br /><searchLink fieldCode="AU" term="%22Spiteri+M%22">Spiteri M</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Cain+SA%22">Cain SA</searchLink>; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Jones+J%22">Jones J</searchLink>; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Shaya+S%22">Shaya S</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Topp+M%22">Topp M</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tobler+R%22">Tobler R</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Valkovic+AL%22">Valkovic AL</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Moore+Z%22">Moore Z</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fatunla+OE%22">Fatunla OE</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kriel+J%22">Kriel J</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Moffet+JJD%22">Moffet JJD</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22McAlpine+H%22">McAlpine H</searchLink>; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rosier+M%22">Rosier M</searchLink>; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Guan+H%22">Guan H</searchLink>; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Dimou+J%22">Dimou J</searchLink>; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Schadewaldt+V%22">Schadewaldt V</searchLink>; Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Roberts-Thomson+S%22">Roberts-Thomson S</searchLink>; Department of Anatomical Pathology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22McArdle+D%22">McArdle D</searchLink>; Department of Medical Imaging, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Radiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lui+E%22">Lui E</searchLink>; Department of Medical Imaging, Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Department of Radiology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Voelker-Albert+M%22">Voelker-Albert M</searchLink>; MoleQlar Analytics GmbH, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22di+Sanzo+S%22">di Sanzo S</searchLink>; MoleQlar Analytics GmbH, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Nijagal+B%22">Nijagal B</searchLink>; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Narayana+VK%22">Narayana VK</searchLink>; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Mitchell+CB%22">Mitchell CB</searchLink>; Department Clinical Pathology, MDHS, University of Melbourne, Melbourne, Victoria, Australia.; Collaborative Centre for Genomic Cancer Medicine, MDHS, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Vissers+JHA%22">Vissers JHA</searchLink>; Department Clinical Pathology, MDHS, University of Melbourne, Melbourne, Victoria, Australia.; Collaborative Centre for Genomic Cancer Medicine, MDHS, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Grimmond+S%22">Grimmond S</searchLink>; Collaborative Centre for Genomic Cancer Medicine, MDHS, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rosenthal+MA%22">Rosenthal MA</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Palmer+LM%22">Palmer LM</searchLink>; The Florey Institute of Neuroscience and Mental Health, The Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Best+SA%22">Best SA</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Freytag+S%22">Freytag S</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Whittle+JR%22">Whittle JR</searchLink>; Personalised Oncology Division, WEHI, Melbourne, Victoria, Australia. whittle.j@wehi.edu.au.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. whittle.j@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia. whittle.j@wehi.edu.au.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2025 Oct; Vol. 31 (10), pp. 3451-3463. <i>Date of Electronic Publication: </i>2025 Aug 21.
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