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Genomic instability and CCNE1 amplification as emerging biomarkers for stratifying high-grade serous ovarian cancer.

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Title: Genomic instability and CCNE1 amplification as emerging biomarkers for stratifying high-grade serous ovarian cancer.
Authors: Conca E; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Lorenzini D; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy., Minna E; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Agnelli L; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Duca M; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Gentili M; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Bodini B; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Polignano M; Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Mantiero M; Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Damian S; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy., Devecchi A; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Dagrada G; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Carminati R; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Ardore A; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Barbetta F; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Da Chuna NB; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Guerrizio A; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Busico A; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Capone I; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Piccolo A; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Tamborini E; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Perrone F; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Milione M; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Paolini B; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Vingiani A; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy., Raspagliesi F; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.; Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., De Braud F; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy., Pruneri G; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.
Source: Frontiers in oncology [Front Oncol] 2025 Aug 06; Vol. 15, pp. 1633410. Date of Electronic Publication: 2025 Aug 06 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Genomic instability and CCNE1 amplification as emerging biomarkers for stratifying high-grade serous ovarian cancer.
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  Data: <searchLink fieldCode="AU" term="%22Conca+E%22">Conca E</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Lorenzini+D%22">Lorenzini D</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Minna+E%22">Minna E</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Agnelli+L%22">Agnelli L</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Duca+M%22">Duca M</searchLink>; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Gentili+M%22">Gentili M</searchLink>; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Bodini+B%22">Bodini B</searchLink>; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Polignano+M%22">Polignano M</searchLink>; Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Mantiero+M%22">Mantiero M</searchLink>; Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Damian+S%22">Damian S</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Devecchi+A%22">Devecchi A</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Dagrada+G%22">Dagrada G</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Carminati+R%22">Carminati R</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Ardore+A%22">Ardore A</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Barbetta+F%22">Barbetta F</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Da+Chuna+NB%22">Da Chuna NB</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Guerrizio+A%22">Guerrizio A</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Busico+A%22">Busico A</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Capone+I%22">Capone I</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Piccolo+A%22">Piccolo A</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Tamborini+E%22">Tamborini E</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Perrone+F%22">Perrone F</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Milione+M%22">Milione M</searchLink>; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Paolini+B%22">Paolini B</searchLink>; Department of Pathology and Laboratory Medicine, Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Vingiani+A%22">Vingiani A</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Raspagliesi+F%22">Raspagliesi F</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.; Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22De+Braud+F%22">De Braud F</searchLink>; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Pruneri+G%22">Pruneri G</searchLink>; Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.
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