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Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics.

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Title: Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics.
Authors: Musolino PL; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St. Lunder Building 6th Floor Boston, MA 02114., Rosser SJ; UK Centre for Mammalian Synthetic Biology at the Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Brittan M; British Heart Foundation Centre for Research Excellence, Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), 7 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK., Newby DE; British Heart Foundation Centre for Research Excellence, Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), 7 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK., Berry C; BHF Glasgow Cardiovascular Research Centre, University of Glasgow and Golden Jubilee National Hospital, Clydebank, UK., Riley PR; Institute of Developmental & Regenerative Medicine (IDRM), IMS-Tetsuya Nakamura Building, Old Road Campus, University of Oxford, Oxford OX3 7TY, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), IMS-Tetsuya Nakamura Building, Old Road Campus, University of Oxford, Oxford OX3 7TY, UK., Giacca M; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, James Black Centre125 Coldharbour Lane, London SE5 9NU, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), King's College London, James Black Centre125 Coldharbour Lane, London, SE5 9NUL., Hajjar RJ; Gene & Cell Therapy Institute, Massachusetts General Brigham, Cambridge, MA 02139, USA., Baker AH; British Heart Foundation Centre for Research Excellence, Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), 7 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; Department of Pathology and CARIM School for Cardiovascular Diseases, Maastricht University, UNS 50, Universiteitssingel 50, Maastricht 6229ER, The Netherlands.
Source: Cardiovascular research [Cardiovasc Res] 2025 Oct 24; Vol. 121 (12), pp. 1843-1855.
Publication Type: Journal Article; Review
Journal Info: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Musolino+PL%22">Musolino PL</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St. Lunder Building 6th Floor Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Rosser+SJ%22">Rosser SJ</searchLink>; UK Centre for Mammalian Synthetic Biology at the Institute of Quantitative Biology, Biochemistry, and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Brittan+M%22">Brittan M</searchLink>; British Heart Foundation Centre for Research Excellence, Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), 7 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.<br /><searchLink fieldCode="AU" term="%22Newby+DE%22">Newby DE</searchLink>; British Heart Foundation Centre for Research Excellence, Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), 7 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.<br /><searchLink fieldCode="AU" term="%22Berry+C%22">Berry C</searchLink>; BHF Glasgow Cardiovascular Research Centre, University of Glasgow and Golden Jubilee National Hospital, Clydebank, UK.<br /><searchLink fieldCode="AU" term="%22Riley+PR%22">Riley PR</searchLink>; Institute of Developmental & Regenerative Medicine (IDRM), IMS-Tetsuya Nakamura Building, Old Road Campus, University of Oxford, Oxford OX3 7TY, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), IMS-Tetsuya Nakamura Building, Old Road Campus, University of Oxford, Oxford OX3 7TY, UK.<br /><searchLink fieldCode="AU" term="%22Giacca+M%22">Giacca M</searchLink>; School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King's College London, James Black Centre125 Coldharbour Lane, London SE5 9NU, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), King's College London, James Black Centre125 Coldharbour Lane, London, SE5 9NUL.<br /><searchLink fieldCode="AU" term="%22Hajjar+RJ%22">Hajjar RJ</searchLink>; Gene & Cell Therapy Institute, Massachusetts General Brigham, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Baker+AH%22">Baker AH</searchLink>; British Heart Foundation Centre for Research Excellence, Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; MRC/BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT), 7 Little France Crescent, University of Edinburgh, Edinburgh EH16 4TJ, UK.; Department of Pathology and CARIM School for Cardiovascular Diseases, Maastricht University, UNS 50, Universiteitssingel 50, Maastricht 6229ER, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%220077427%22">Cardiovascular research</searchLink> [Cardiovasc Res] 2025 Oct 24; Vol. 121 (12), pp. 1843-1855.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+Journals%22">Oxford Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0077427 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1755-3245 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200086363%22">00086363 </searchLink><i>NLM ISO Abbreviation: </i>Cardiovasc Res <i>Subsets: </i>MEDLINE
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        Value: 10.1093/cvr/cvaf109
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              Text: 2025 Oct 24
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