View in EDS HTML Full Text PDF Full Text

High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas.

Saved in:
Bibliographic Details
Title: High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas.
Authors: Herter S; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Emperador M; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Smyrilli K; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Kocher D; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Celikyürekli S; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany., Zeiser C; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany., Gerloff X; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Mathematics and Computer Science, Heidelberg University, 69120, Heidelberg, Germany., Kreth S; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Neuroblastoma Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Henrich KO; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Neuroblastoma Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Maaß KK; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Division of Pediatric Neurooncology, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Rettenmeier J; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Division of Pediatric Neurooncology, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Grünewald TGP; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Peterziel H; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany., Westermann F; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Neuroblastoma Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Hamacher-Brady A; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany., Oehme I; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.
Source: Cell death & disease [Cell Death Dis] 2025 Aug 25; Vol. 16 (1), pp. 644. Date of Electronic Publication: 2025 Aug 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40854877
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Herter+S%22">Herter S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Emperador+M%22">Emperador M</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Smyrilli+K%22">Smyrilli K</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kocher+D%22">Kocher D</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Celikyürekli+S%22">Celikyürekli S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zeiser+C%22">Zeiser C</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gerloff+X%22">Gerloff X</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Faculty of Mathematics and Computer Science, Heidelberg University, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kreth+S%22">Kreth S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Neuroblastoma Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Henrich+KO%22">Henrich KO</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Neuroblastoma Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Maaß+KK%22">Maaß KK</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Division of Pediatric Neurooncology, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rettenmeier+J%22">Rettenmeier J</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Division of Pediatric Neurooncology, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Grünewald+TGP%22">Grünewald TGP</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Peterziel+H%22">Peterziel H</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Westermann+F%22">Westermann F</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Neuroblastoma Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hamacher-Brady+A%22">Hamacher-Brady A</searchLink>; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Witt+O%22">Witt O</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Oehme+I%22">Oehme I</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), 69120, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120, Heidelberg, Germany. i.oehme@kitz-heidelberg.de.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2025 Aug 25; Vol. 16 (1), pp. 644. <i>Date of Electronic Publication: </i>2025 Aug 25.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40854877
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41419-025-07933-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 644
    Titles:
      – TitleFull: High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Herter S
      – PersonEntity:
          Name:
            NameFull: Emperador M
      – PersonEntity:
          Name:
            NameFull: Smyrilli K
      – PersonEntity:
          Name:
            NameFull: Kocher D
      – PersonEntity:
          Name:
            NameFull: Celikyürekli S
      – PersonEntity:
          Name:
            NameFull: Zeiser C
      – PersonEntity:
          Name:
            NameFull: Gerloff X
      – PersonEntity:
          Name:
            NameFull: Kreth S
      – PersonEntity:
          Name:
            NameFull: Henrich KO
      – PersonEntity:
          Name:
            NameFull: Maaß KK
      – PersonEntity:
          Name:
            NameFull: Rettenmeier J
      – PersonEntity:
          Name:
            NameFull: Grünewald TGP
      – PersonEntity:
          Name:
            NameFull: Peterziel H
      – PersonEntity:
          Name:
            NameFull: Westermann F
      – PersonEntity:
          Name:
            NameFull: Hamacher-Brady A
      – PersonEntity:
          Name:
            NameFull: Witt O
      – PersonEntity:
          Name:
            NameFull: Oehme I
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 08
              Text: 2025 Aug 25
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-4889
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Cell death & disease
              Type: main
ResultId 1