Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis.

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Title: Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis.
Authors: Sarkar S; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA., Liu HY; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA., Yuan F; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA., Malady BT; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA., Wang L; Department of Biochemistry and Structural Biology, The University of Texas Health, Science Center at San Antonio, San Antonio, TX, USA., Lafer EM; Department of Biochemistry and Structural Biology, The University of Texas Health, Science Center at San Antonio, San Antonio, TX, USA., Perez J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Huibregtse JM; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Stachowiak JC; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA. jcstach@austin.utexas.edu.; McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA. jcstach@austin.utexas.edu.
Source: Nature communications [Nat Commun] 2025 Aug 25; Vol. 16 (1), pp. 7929. Date of Electronic Publication: 2025 Aug 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-63238-z