Simultaneous Determination of Osimertinib and its Metabolites in Human Plasma for Clinical Applications Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

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Title: Simultaneous Determination of Osimertinib and its Metabolites in Human Plasma for Clinical Applications Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.
Authors: Wu J; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China., Guo L; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou University City, Guangzhou, China., Zhou G; Department of Pharmacy, Guangxi Medical University Cancer Hospital, Nanning, China ; and., Wang Y; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou University City, Guangzhou, China., Tang KJ; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China., Xu J; Department of Pharmacy, Dermatology Hospital, Southern Medical University, Guangzhou, China ., Chen J; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Source: Therapeutic drug monitoring [Ther Drug Monit] 2025 Dec 01; Vol. 47 (6), pp. 747-754. Date of Electronic Publication: 2025 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7909660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-3694 (Electronic) Linking ISSN: 01634356 NLM ISO Abbreviation: Ther Drug Monit Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Simultaneous Determination of Osimertinib and its Metabolites in Human Plasma for Clinical Applications Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.
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  Data: <searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Guo+L%22">Guo L</searchLink>; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou University City, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+G%22">Zhou G</searchLink>; Department of Pharmacy, Guangxi Medical University Cancer Hospital, Nanning, China ; and.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou University City, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Tang+KJ%22">Tang KJ</searchLink>; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Pharmacy, Dermatology Hospital, Southern Medical University, Guangzhou, China .<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
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      – TitleFull: Simultaneous Determination of Osimertinib and its Metabolites in Human Plasma for Clinical Applications Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.
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              Text: 2025 Dec 01
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