AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions. - Swaih AM; Talbot S; Savoca A; Thorpe H; Flemington V; Phillips B; Colclough N; McCoull W; Radeva V; Hargreaves D; Packer MJ; Felisberto-Rodrigues C; et al. (Cell reports. Medicine, 2025)