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Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation.

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Title: Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation.
Authors: Mahul-Mellier AL; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; UPDANGELO, Institute of Bioengineering and Global Health Institute, EPFL,, Lausanne, Switzerland., Altay MF; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Stanford Medicine, Department of Neurology and Neurological Sciences, Palo Alto, CA, USA., Maharjan N; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Ait-Bouziad N; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Chiki A; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Jagannath S; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Limorenko G; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Novello S; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Ricci J; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Jasiqi Y; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; UPDANGELO, Institute of Bioengineering and Global Health Institute, EPFL,, Lausanne, Switzerland., Vingill S; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Wade-Martins R; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Holton J; Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Strand C; Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Haikal C; Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden., Li JY; Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Institute of Health Sciences, China Medical University, Shenyang, China., Hamelin R; Proteomic Core Facility and Technology Platform, EPFL, Lausanne, Switzerland., Croisier M; BioEM Core Facility and Technology Platform, EPFL, Lausanne, Switzerland., Knott G; BioEM Core Facility and Technology Platform, EPFL, Lausanne, Switzerland., Mairet-Coello G; UCB Biopharma SPRL, Braine-l'Alleud, Belgium., Weerens L; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; UCB Biopharma SPRL, Braine-l'Alleud, Belgium., Michel A; UCB Biopharma SPRL, Braine-l'Alleud, Belgium., Downey P; UCB Biopharma SPRL, Braine-l'Alleud, Belgium., Citron M; UCB Biopharma SPRL, Braine-l'Alleud, Belgium., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. hilal.lashuel@epfl.ch.; Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar. hilal.lashuel@epfl.ch.; Department of Neurology, Weill Cornell Medicine, New York, NY, USA. hilal.lashuel@epfl.ch.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Aug 26; Vol. 11 (1), pp. 261. Date of Electronic Publication: 2025 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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  Data: Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation.
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  Data: <searchLink fieldCode="AU" term="%22Mahul-Mellier+AL%22">Mahul-Mellier AL</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; UPDANGELO, Institute of Bioengineering and Global Health Institute, EPFL,, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Altay+MF%22">Altay MF</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Stanford Medicine, Department of Neurology and Neurological Sciences, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Maharjan+N%22">Maharjan N</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ait-Bouziad+N%22">Ait-Bouziad N</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chiki+A%22">Chiki A</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jagannath+S%22">Jagannath S</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Limorenko+G%22">Limorenko G</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Novello+S%22">Novello S</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ricci+J%22">Ricci J</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jasiqi+Y%22">Jasiqi Y</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; UPDANGELO, Institute of Bioengineering and Global Health Institute, EPFL,, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vingill+S%22">Vingill S</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wade-Martins+R%22">Wade-Martins R</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Holton+J%22">Holton J</searchLink>; Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Strand+C%22">Strand C</searchLink>; Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Haikal+C%22">Haikal C</searchLink>; Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Li+JY%22">Li JY</searchLink>; Neural Plasticity and Repair Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Institute of Health Sciences, China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Hamelin+R%22">Hamelin R</searchLink>; Proteomic Core Facility and Technology Platform, EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Croisier+M%22">Croisier M</searchLink>; BioEM Core Facility and Technology Platform, EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Knott+G%22">Knott G</searchLink>; BioEM Core Facility and Technology Platform, EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mairet-Coello+G%22">Mairet-Coello G</searchLink>; UCB Biopharma SPRL, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Weerens+L%22">Weerens L</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; UCB Biopharma SPRL, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Michel+A%22">Michel A</searchLink>; UCB Biopharma SPRL, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Downey+P%22">Downey P</searchLink>; UCB Biopharma SPRL, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Citron+M%22">Citron M</searchLink>; UCB Biopharma SPRL, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Lashuel+HA%22">Lashuel HA</searchLink>; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. hilal.lashuel@epfl.ch.; Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar. hilal.lashuel@epfl.ch.; Department of Neurology, Weill Cornell Medicine, New York, NY, USA. hilal.lashuel@epfl.ch.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2025 Aug 26; Vol. 11 (1), pp. 261. <i>Date of Electronic Publication: </i>2025 Aug 26.
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