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Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors.

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Title: Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors.
Authors: Dodda LS; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Campos S; Pharmaron, Hoddesdon EN119FH, U.K., Ciccone D; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Carreiro S; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Leit S; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Brennan D; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Zephyr J; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Jacques-O'Hagan S; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Kumar S; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Kuo FS; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Shaik MM; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Price DJ; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Loh C; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Edmondson SD; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Tummino P; Nimbus Therapeutics, Boston, Massachusetts 02210, United States., Kaila N; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Sep 11; Vol. 68 (17), pp. 18436-18462. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Dodda+LS%22">Dodda LS</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Campos+S%22">Campos S</searchLink>; Pharmaron, Hoddesdon EN119FH, U.K.<br /><searchLink fieldCode="AU" term="%22Ciccone+D%22">Ciccone D</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Carreiro+S%22">Carreiro S</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Leit+S%22">Leit S</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Brennan+D%22">Brennan D</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Zephyr+J%22">Zephyr J</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Jacques-O'Hagan+S%22">Jacques-O'Hagan S</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Kuo+FS%22">Kuo FS</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Shaik+MM%22">Shaik MM</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Price+DJ%22">Price DJ</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Loh+C%22">Loh C</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Edmondson+SD%22">Edmondson SD</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Tummino+P%22">Tummino P</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.<br /><searchLink fieldCode="AU" term="%22Kaila+N%22">Kaila N</searchLink>; Nimbus Therapeutics, Boston, Massachusetts 02210, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Sep 11; Vol. 68 (17), pp. 18436-18462. <i>Date of Electronic Publication: </i>2025 Aug 27.
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        Value: 10.1021/acs.jmedchem.5c01231
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              Text: 2025 Sep 11
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