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The impact of fitness and dose intensity on clinical outcomes with venetoclax-obinutuzumab in CLL.

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Title: The impact of fitness and dose intensity on clinical outcomes with venetoclax-obinutuzumab in CLL.
Authors: Al-Sawaf O; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Fürstenau M; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Giza A; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Robrecht S; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., von Tresckow J; Department of Hematology, Oncology and Palliative Care, Katholisches Klinikum Bochum, Ruhr University Bochum, Bochum, Germany., Fink AM; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Simon F; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Tausch E; Division of Chronic Lymphocytic Leukaemia, Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany., Schneider C; Division of Chronic Lymphocytic Leukaemia, Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany., Sivcheva L; First Department of Internal Medicine, Hristo Botev Multiprofile Hospital for Active Treatment, Vratsa, Bulgaria., Schwarer A; Department of Haematology, Box Hill Hospital, Melbourne, Australia., Loscertales J; Hematology Department, Hospital De La Princesa, Madrid, Spain., Weinkove R; Te Rerenga Ora Wellington Blood and Cancer Centre, Te Whatu Ora Health New Zealand Capital, Wellington, New Zealand.; Cancer Immunotherapy Program, Malaghan Institute of Medical Research, Wellington, New Zealand., Strumberg D; Medical Department III, Hematology/Oncology, Marien Hospital Herne, University Hospitals of the Ruhr University Bochum, Bochum, Germany., Kilfoyle A; Haematology Department, Palmerston North Hospital, Palmerston North, New Zealand., Juliusson G; Department of Haematology, Lund University Cancer Center, Lund, Sweden., da Cunha-Bang C; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Illmer T; Praxis of Haematology and Oncology, Dresden, Germany., Gregor M; Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland., Thornton P; Department of Haematology, Beaumont Hospital, Dublin, Ireland., Janssens A; Department of Oncology, University Hospitals Leuven, Leuven, Belgium., Tadmor T; Deoartment of Hematology, Bnai-Zion Medical Center, Haifa, Israel., Lindström V; Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Staber P; Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Levin MD; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands., Wendtner CM; Department of Medicine III and Comprehensive Cancer Center (Munich), Ludwig-Maximilians University Hospital, Ludwig Maximilian University, Munich, Germany., Kreuzer KA; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Ritgen M; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany., Stilgenbauer S; Division of Chronic Lymphocytic Leukaemia, Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany., Kater AP; Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands., Niemann C; Department of Hematology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Fischer K; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Eichhorst B; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Hallek M; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Source: Blood [Blood] 2025 Nov 13; Vol. 146 (20), pp. 2406-2416.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: The impact of fitness and dose intensity on clinical outcomes with venetoclax-obinutuzumab in CLL.
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  Data: <searchLink fieldCode="AU" term="%22Al-Sawaf+O%22">Al-Sawaf O</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fürstenau+M%22">Fürstenau M</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Giza+A%22">Giza A</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Robrecht+S%22">Robrecht S</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22von+Tresckow+J%22">von Tresckow J</searchLink>; Department of Hematology, Oncology and Palliative Care, Katholisches Klinikum Bochum, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Fink+AM%22">Fink AM</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+F%22">Simon F</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Tausch+E%22">Tausch E</searchLink>; Division of Chronic Lymphocytic Leukaemia, Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+C%22">Schneider C</searchLink>; Division of Chronic Lymphocytic Leukaemia, Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Sivcheva+L%22">Sivcheva L</searchLink>; First Department of Internal Medicine, Hristo Botev Multiprofile Hospital for Active Treatment, Vratsa, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Schwarer+A%22">Schwarer A</searchLink>; Department of Haematology, Box Hill Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Loscertales+J%22">Loscertales J</searchLink>; Hematology Department, Hospital De La Princesa, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Weinkove+R%22">Weinkove R</searchLink>; Te Rerenga Ora Wellington Blood and Cancer Centre, Te Whatu Ora Health New Zealand Capital, Wellington, New Zealand.; Cancer Immunotherapy Program, Malaghan Institute of Medical Research, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Strumberg+D%22">Strumberg D</searchLink>; Medical Department III, Hematology/Oncology, Marien Hospital Herne, University Hospitals of the Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Kilfoyle+A%22">Kilfoyle A</searchLink>; Haematology Department, Palmerston North Hospital, Palmerston North, New Zealand.<br /><searchLink fieldCode="AU" term="%22Juliusson+G%22">Juliusson G</searchLink>; Department of Haematology, Lund University Cancer Center, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22da+Cunha-Bang+C%22">da Cunha-Bang C</searchLink>; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Illmer+T%22">Illmer T</searchLink>; Praxis of Haematology and Oncology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Gregor+M%22">Gregor M</searchLink>; Division of Hematology, Cantonal Hospital of Lucerne, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Thornton+P%22">Thornton P</searchLink>; Department of Haematology, Beaumont Hospital, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Janssens+A%22">Janssens A</searchLink>; Department of Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Tadmor+T%22">Tadmor T</searchLink>; Deoartment of Hematology, Bnai-Zion Medical Center, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Lindström+V%22">Lindström V</searchLink>; Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Staber+P%22">Staber P</searchLink>; Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Levin+MD%22">Levin MD</searchLink>; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wendtner+CM%22">Wendtner CM</searchLink>; Department of Medicine III and Comprehensive Cancer Center (Munich), Ludwig-Maximilians University Hospital, Ludwig Maximilian University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kreuzer+KA%22">Kreuzer KA</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ritgen+M%22">Ritgen M</searchLink>; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Stilgenbauer+S%22">Stilgenbauer S</searchLink>; Division of Chronic Lymphocytic Leukaemia, Department III of Internal Medicine, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Kater+AP%22">Kater AP</searchLink>; Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Niemann+C%22">Niemann C</searchLink>; Department of Hematology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Fischer+K%22">Fischer K</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Eichhorst+B%22">Eichhorst B</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hallek+M%22">Hallek M</searchLink>; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
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