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CD371-targeted CAR T cells secreting interleukin-18 exhibit robust expansion and clear refractory acute myeloid leukemia.

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Title: CD371-targeted CAR T cells secreting interleukin-18 exhibit robust expansion and clear refractory acute myeloid leukemia.
Authors: Geyer MB; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY., DeWolf S; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY., Mi X; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY., Weis K; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Shaffer BC; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY., Cadzin B; Department of Nursing, Memorial Sloan Kettering Cancer Center, New York, NY., McAvoy D; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY., Katsamakis Z; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY., Lorenc R; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY., Lewis AM; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Gipson B; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Cuibus MA; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Girotra NN; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Wu K; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY., Smith N; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY., Burns ER; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY., Um JS; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY., Yoo S; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY., Masouleh BK; Tigen Pharma, Lausanne, Switzerland., Galera P; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Hosszu K; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY., Chaudhari J; Biotherapeutics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY., Wang X; Biotherapeutics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY., Lin Q; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY., Curran KJ; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY., Park JH; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY., Scheinberg DA; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY.; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., van den Brink MRM; Hematologic Malignancies Program, City of Hope National Medical Center, Duarte, CA., Abdel-Wahab O; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY., Brentjens RJ; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Daniyan AF; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Source: Blood [Blood] 2025 Dec 25; Vol. 146 (26), pp. 3163-3174.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CD371-targeted CAR T cells secreting interleukin-18 exhibit robust expansion and clear refractory acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Geyer+MB%22">Geyer MB</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22DeWolf+S%22">DeWolf S</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Mi+X%22">Mi X</searchLink>; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Weis+K%22">Weis K</searchLink>; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Shaffer+BC%22">Shaffer BC</searchLink>; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Cadzin+B%22">Cadzin B</searchLink>; Department of Nursing, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22McAvoy+D%22">McAvoy D</searchLink>; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Katsamakis+Z%22">Katsamakis Z</searchLink>; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Lorenc+R%22">Lorenc R</searchLink>; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY.<br /><searchLink fieldCode="AU" term="%22Lewis+AM%22">Lewis AM</searchLink>; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Gipson+B%22">Gipson B</searchLink>; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Cuibus+MA%22">Cuibus MA</searchLink>; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Girotra+NN%22">Girotra NN</searchLink>; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Smith+N%22">Smith N</searchLink>; Department of Medicine, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Burns+ER%22">Burns ER</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Um+JS%22">Um JS</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Yoo+S%22">Yoo S</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Masouleh+BK%22">Masouleh BK</searchLink>; Tigen Pharma, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Galera+P%22">Galera P</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Hosszu+K%22">Hosszu K</searchLink>; Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Chaudhari+J%22">Chaudhari J</searchLink>; Biotherapeutics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Biotherapeutics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Lin+Q%22">Lin Q</searchLink>; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY.<br /><searchLink fieldCode="AU" term="%22Curran+KJ%22">Curran KJ</searchLink>; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Scheinberg+DA%22">Scheinberg DA</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY.; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22van+den+Brink+MRM%22">van den Brink MRM</searchLink>; Hematologic Malignancies Program, City of Hope National Medical Center, Duarte, CA.<br /><searchLink fieldCode="AU" term="%22Abdel-Wahab+O%22">Abdel-Wahab O</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Pharmacology Program, Graduate School of Medical Sciences, Weill Cornell Medical College, New York, NY.<br /><searchLink fieldCode="AU" term="%22Brentjens+RJ%22">Brentjens RJ</searchLink>; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY.<br /><searchLink fieldCode="AU" term="%22Daniyan+AF%22">Daniyan AF</searchLink>; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.
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  Data: <searchLink fieldCode="JN" term="%227603509%22">Blood</searchLink> [Blood] 2025 Dec 25; Vol. 146 (26), pp. 3163-3174.
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              Text: 2025 Dec 25
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