View in EDS

Randomised trial of trastuzumab deruxtecan and biology-driven selection of neoadjuvant treatment for HER2-positive breast cancer: a study protocol of ARIADNE.

Saved in:
Bibliographic Details
Title: Randomised trial of trastuzumab deruxtecan and biology-driven selection of neoadjuvant treatment for HER2-positive breast cancer: a study protocol of ARIADNE.
Authors: Matikas A; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden alexios.matikas@ki.se.; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden., Naume B; Department of Oncology, Oslo University Hospital, Oslo, Norway., Wildiers H; Department of General Medical Oncology and Multidisciplinary Breast Centre, University Hospitals Leuven, Leuven, Belgium., Sonke G; Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Dieci MV; Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Università di Padova, Padova, Italy.; Oncologia 2, Istituto Oncologico Veneto IRCCS, Padova, Italy., Karakatsanis A; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; Section for Breast Surgery, Uppsala University Hospital (Akademiska), Uppsala, Sweden., Andersson A; Department of diagnostics and intervention, oncology, Umeå University, Umeå, Sweden., Barnekow E; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Department of Oncology, Södersjukhuset, Stockholm, Sweden., Kessler LE; Breast Center, Capio Saint Göran's Hospital, Stockholm, Sweden., Einbeigi Z; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Medicine and Oncology, Southern Älvsborg Hospital, Borås, Sweden., Killander F; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Skåne University Hospital, Lund University, Lund, Sweden., Linderholm B; Institution of Clinical Sciences, Department of Oncology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden., Schiza A; Department of Oncology, Uppsala University Hospital and department of Immunology, Genetics and Pathology Uppsala University, Uppsala, Sweden., Valachis A; Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Nearchou A; Department of Oncology, Mälarsjukhuset, Eskilstuna, Sweden., Engebraaten O; Department of Oncology, Oslo University Hospital, Oslo, Norway., Porojnicu A; Department of Oncology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway., Soland MH; Department of Oncology, Stavanger University Hospital, Stavanger, Norway., Mannsåker B; Department of Oncology, Nordland Hospital Trust, Bodø, Norway., Raj SX; Breast Cancer Unit, Cancer Clinic, University Hospital in Trondheim, Trondheim, Norway., Blix ES; Department of Oncology, University Hospital of North Norway, Tromsø, Norway., Nordstrand CS; Department of Oncology, Møre og Romsdal Hospital Trust, Alesund, Norway., Lambertini M; Department of Medical Oncology, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genova, Genova, Italy., Vernieri C; Medical Oncology Department, Breast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.; Oncology and Hematology-Oncology Department, University of Milan, Milan, Italy., Punie K; Department of Medical Oncology, Ziekenhuis Aan de Stroom, Wilrijk, Belgium., Sotiriou C; Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium., Bergh J; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden.; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden., Villacampa G; SOLTI Cancer Research Group, Barcelona, Spain.; Statistics Unit, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Zouzos A; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden., Hellström M; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden., Hartman J; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Foukakis T; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden.; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.
Source: BMJ open [BMJ Open] 2025 Aug 27; Vol. 15 (8), pp. e102626. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40866060
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Randomised trial of trastuzumab deruxtecan and biology-driven selection of neoadjuvant treatment for HER2-positive breast cancer: a study protocol of ARIADNE.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Matikas+A%22">Matikas A</searchLink>; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden alexios.matikas@ki.se.; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Naume+B%22">Naume B</searchLink>; Department of Oncology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Wildiers+H%22">Wildiers H</searchLink>; Department of General Medical Oncology and Multidisciplinary Breast Centre, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sonke+G%22">Sonke G</searchLink>; Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dieci+MV%22">Dieci MV</searchLink>; Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Università di Padova, Padova, Italy.; Oncologia 2, Istituto Oncologico Veneto IRCCS, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Karakatsanis+A%22">Karakatsanis A</searchLink>; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; Section for Breast Surgery, Uppsala University Hospital (Akademiska), Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Andersson+A%22">Andersson A</searchLink>; Department of diagnostics and intervention, oncology, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Barnekow+E%22">Barnekow E</searchLink>; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Department of Oncology, Södersjukhuset, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kessler+LE%22">Kessler LE</searchLink>; Breast Center, Capio Saint Göran's Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Einbeigi+Z%22">Einbeigi Z</searchLink>; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Medicine and Oncology, Southern Älvsborg Hospital, Borås, Sweden.<br /><searchLink fieldCode="AU" term="%22Killander+F%22">Killander F</searchLink>; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Skåne University Hospital, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Linderholm+B%22">Linderholm B</searchLink>; Institution of Clinical Sciences, Department of Oncology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Schiza+A%22">Schiza A</searchLink>; Department of Oncology, Uppsala University Hospital and department of Immunology, Genetics and Pathology Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Valachis+A%22">Valachis A</searchLink>; Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.<br /><searchLink fieldCode="AU" term="%22Nearchou+A%22">Nearchou A</searchLink>; Department of Oncology, Mälarsjukhuset, Eskilstuna, Sweden.<br /><searchLink fieldCode="AU" term="%22Engebraaten+O%22">Engebraaten O</searchLink>; Department of Oncology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Porojnicu+A%22">Porojnicu A</searchLink>; Department of Oncology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.<br /><searchLink fieldCode="AU" term="%22Soland+MH%22">Soland MH</searchLink>; Department of Oncology, Stavanger University Hospital, Stavanger, Norway.<br /><searchLink fieldCode="AU" term="%22Mannsåker+B%22">Mannsåker B</searchLink>; Department of Oncology, Nordland Hospital Trust, Bodø, Norway.<br /><searchLink fieldCode="AU" term="%22Raj+SX%22">Raj SX</searchLink>; Breast Cancer Unit, Cancer Clinic, University Hospital in Trondheim, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Blix+ES%22">Blix ES</searchLink>; Department of Oncology, University Hospital of North Norway, Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22Nordstrand+CS%22">Nordstrand CS</searchLink>; Department of Oncology, Møre og Romsdal Hospital Trust, Alesund, Norway.<br /><searchLink fieldCode="AU" term="%22Lambertini+M%22">Lambertini M</searchLink>; Department of Medical Oncology, U.O. Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.; Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genova, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Vernieri+C%22">Vernieri C</searchLink>; Medical Oncology Department, Breast Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.; Oncology and Hematology-Oncology Department, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Punie+K%22">Punie K</searchLink>; Department of Medical Oncology, Ziekenhuis Aan de Stroom, Wilrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22Sotiriou+C%22">Sotiriou C</searchLink>; Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Bergh+J%22">Bergh J</searchLink>; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden.; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Villacampa+G%22">Villacampa G</searchLink>; SOLTI Cancer Research Group, Barcelona, Spain.; Statistics Unit, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Zouzos+A%22">Zouzos A</searchLink>; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hellström+M%22">Hellström M</searchLink>; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hartman+J%22">Hartman J</searchLink>; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Foukakis+T%22">Foukakis T</searchLink>; Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden.; Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 Aug 27; Vol. 15 (8), pp. e102626. <i>Date of Electronic Publication: </i>2025 Aug 27.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Clinical Trial Protocol
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101552874 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2044-6055 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220446055%22">20446055 </searchLink><i>NLM ISO Abbreviation: </i>BMJ Open <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40866060
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1136/bmjopen-2025-102626
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e102626
    Titles:
      – TitleFull: Randomised trial of trastuzumab deruxtecan and biology-driven selection of neoadjuvant treatment for HER2-positive breast cancer: a study protocol of ARIADNE.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Matikas A
      – PersonEntity:
          Name:
            NameFull: Naume B
      – PersonEntity:
          Name:
            NameFull: Wildiers H
      – PersonEntity:
          Name:
            NameFull: Sonke G
      – PersonEntity:
          Name:
            NameFull: Dieci MV
      – PersonEntity:
          Name:
            NameFull: Karakatsanis A
      – PersonEntity:
          Name:
            NameFull: Andersson A
      – PersonEntity:
          Name:
            NameFull: Barnekow E
      – PersonEntity:
          Name:
            NameFull: Kessler LE
      – PersonEntity:
          Name:
            NameFull: Einbeigi Z
      – PersonEntity:
          Name:
            NameFull: Killander F
      – PersonEntity:
          Name:
            NameFull: Linderholm B
      – PersonEntity:
          Name:
            NameFull: Schiza A
      – PersonEntity:
          Name:
            NameFull: Valachis A
      – PersonEntity:
          Name:
            NameFull: Nearchou A
      – PersonEntity:
          Name:
            NameFull: Engebraaten O
      – PersonEntity:
          Name:
            NameFull: Porojnicu A
      – PersonEntity:
          Name:
            NameFull: Soland MH
      – PersonEntity:
          Name:
            NameFull: Mannsåker B
      – PersonEntity:
          Name:
            NameFull: Raj SX
      – PersonEntity:
          Name:
            NameFull: Blix ES
      – PersonEntity:
          Name:
            NameFull: Nordstrand CS
      – PersonEntity:
          Name:
            NameFull: Lambertini M
      – PersonEntity:
          Name:
            NameFull: Vernieri C
      – PersonEntity:
          Name:
            NameFull: Punie K
      – PersonEntity:
          Name:
            NameFull: Sotiriou C
      – PersonEntity:
          Name:
            NameFull: Bergh J
      – PersonEntity:
          Name:
            NameFull: Villacampa G
      – PersonEntity:
          Name:
            NameFull: Zouzos A
      – PersonEntity:
          Name:
            NameFull: Hellström M
      – PersonEntity:
          Name:
            NameFull: Hartman J
      – PersonEntity:
          Name:
            NameFull: Foukakis T
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 27
              M: 08
              Text: 2025 Aug 27
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2044-6055
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: BMJ open
              Type: main
ResultId 1