Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health.
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| Title: | Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health. |
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| Authors: | Tsourmas KI; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Butler CA; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Kwang NE; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Sloane ZR; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Dykman KJG; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Maloof GO; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Choudhury BP; GlycoAnalytics Core, Glycobiology Research and Training Center, School of Medicine, University of California, San Diego, CA, USA., Paulchakrabarti M; GlycoAnalytics Core, Glycobiology Research and Training Center, School of Medicine, University of California, San Diego, CA, USA., Prekopa CA; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Tabaie EZ; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Krattli RP; Department of Anatomy and Neurobiology; University of California, Irvine, CA, USA., El-Khatib SM; Department of Anatomy and Neurobiology; University of California, Irvine, CA, USA., Swarup V; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Acharya MM; Department of Anatomy and Neurobiology; University of California, Irvine, CA, USA.; Department of Radiation Oncology; University of California, Irvine, CA, USA., Hohsfield LA; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA., Green KN; Department of Neurobiology and Behavior; University of California, Irvine, CA, USA. kngreen@uci.edu.; Institute for Memory Impairments and Neurological Disorders; University of California, Irvine, CA, USA. kngreen@uci.edu. |
| Source: | Nature communications [Nat Commun] 2025 Aug 27; Vol. 16 (1), pp. 7994. Date of Electronic Publication: 2025 Aug 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-63237-0 |
