Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health. - Tsourmas KI; Butler CA; Kwang NE; Sloane ZR; Dykman KJG; Maloof GO; Choudhury BP; Paulchakrabarti M; Prekopa CA; Tabaie EZ; Krattli RP; El-Khatib SM; et al. (Nature communications, 2025)