The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.
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| Title: | The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells. |
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| Authors: | Zach R; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. r.zach@sussex.ac.uk., Annis M; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Martin-Guerrero SM; Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Alatawi A; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Chia KH; University College London Cancer Institute, London, WC1E 6DD, UK., Meredith M; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Osborn K; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Peter N; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Pearce W; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Booth J; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Rajasekaran M; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Dias S; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Coleman-Evans L; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Foster WR; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Harper JA; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Herbert AD; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Tighe C; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Reuillon T; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., West R; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Busby O; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Burdova K; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Crepin D; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Ortoll S; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Vaeteewoottacharn K; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Dejsuphong D; Program in Translational Medicine, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samutprakarn, 10540, Thailand., Spencer J; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Patel H; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK., Le Grand D; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK., Hunt TA; Oncology Chemistry, Oncology Targeted Discovery, AstraZeneca, Cambridge, CB2 0AA, UK., Andrews DM; Oncology Chemistry, Oncology Targeted Discovery, AstraZeneca, Cambridge, CB2 0AA, UK., Yamano H; University College London Cancer Institute, London, WC1E 6DD, UK., Cutillas PR; Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Oliver AW; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Ward SE; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK., Hochegger H; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. h.hochegger@sussex.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Aug 27; Vol. 16 (1), pp. 8016. Date of Electronic Publication: 2025 Aug 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-62943-z |
