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The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.

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Title: The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.
Authors: Zach R; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. r.zach@sussex.ac.uk., Annis M; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Martin-Guerrero SM; Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Alatawi A; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Chia KH; University College London Cancer Institute, London, WC1E 6DD, UK., Meredith M; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Osborn K; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Peter N; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Pearce W; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Booth J; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Rajasekaran M; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Dias S; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Coleman-Evans L; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Foster WR; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Harper JA; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Herbert AD; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Tighe C; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Reuillon T; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., West R; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Busby O; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Burdova K; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Crepin D; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Ortoll S; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Vaeteewoottacharn K; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand., Dejsuphong D; Program in Translational Medicine, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samutprakarn, 10540, Thailand., Spencer J; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK., Patel H; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK., Le Grand D; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK., Hunt TA; Oncology Chemistry, Oncology Targeted Discovery, AstraZeneca, Cambridge, CB2 0AA, UK., Andrews DM; Oncology Chemistry, Oncology Targeted Discovery, AstraZeneca, Cambridge, CB2 0AA, UK., Yamano H; University College London Cancer Institute, London, WC1E 6DD, UK., Cutillas PR; Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Oliver AW; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK., Ward SE; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK., Hochegger H; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. h.hochegger@sussex.ac.uk.
Source: Nature communications [Nat Commun] 2025 Aug 27; Vol. 16 (1), pp. 8016. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Zach+R%22">Zach R</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. r.zach@sussex.ac.uk.<br /><searchLink fieldCode="AU" term="%22Annis+M%22">Annis M</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Martin-Guerrero+SM%22">Martin-Guerrero SM</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Alatawi+A%22">Alatawi A</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Chia+KH%22">Chia KH</searchLink>; University College London Cancer Institute, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Meredith+M%22">Meredith M</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Osborn+K%22">Osborn K</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Peter+N%22">Peter N</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Pearce+W%22">Pearce W</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Booth+J%22">Booth J</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Rajasekaran+M%22">Rajasekaran M</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Dias+S%22">Dias S</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Coleman-Evans+L%22">Coleman-Evans L</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Foster+WR%22">Foster WR</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Harper+JA%22">Harper JA</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Herbert+AD%22">Herbert AD</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Tighe+C%22">Tighe C</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Reuillon+T%22">Reuillon T</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22West+R%22">West R</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Busby+O%22">Busby O</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Burdova+K%22">Burdova K</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Crepin+D%22">Crepin D</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Ortoll+S%22">Ortoll S</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Vaeteewoottacharn+K%22">Vaeteewoottacharn K</searchLink>; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.<br /><searchLink fieldCode="AU" term="%22Dejsuphong+D%22">Dejsuphong D</searchLink>; Program in Translational Medicine, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samutprakarn, 10540, Thailand.<br /><searchLink fieldCode="AU" term="%22Spencer+J%22">Spencer J</searchLink>; Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.<br /><searchLink fieldCode="AU" term="%22Patel+H%22">Patel H</searchLink>; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Le+Grand+D%22">Le Grand D</searchLink>; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Hunt+TA%22">Hunt TA</searchLink>; Oncology Chemistry, Oncology Targeted Discovery, AstraZeneca, Cambridge, CB2 0AA, UK.<br /><searchLink fieldCode="AU" term="%22Andrews+DM%22">Andrews DM</searchLink>; Oncology Chemistry, Oncology Targeted Discovery, AstraZeneca, Cambridge, CB2 0AA, UK.<br /><searchLink fieldCode="AU" term="%22Yamano+H%22">Yamano H</searchLink>; University College London Cancer Institute, London, WC1E 6DD, UK.<br /><searchLink fieldCode="AU" term="%22Cutillas+PR%22">Cutillas PR</searchLink>; Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Oliver+AW%22">Oliver AW</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK.<br /><searchLink fieldCode="AU" term="%22Ward+SE%22">Ward SE</searchLink>; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Hochegger+H%22">Hochegger H</searchLink>; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, BN1 9RQ, UK. h.hochegger@sussex.ac.uk.
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