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Crystal structures of agonist-bound human cannabinoid receptor CB1.

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Title: Crystal structures of agonist-bound human cannabinoid receptor CB1.
Authors: Hua T; iHuman Institute, ShanghaiTech University, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Vemuri K; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA., Nikas SP; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA., Wu Y; iHuman Institute, ShanghaiTech University, Shanghai, China., Qu L; iHuman Institute, ShanghaiTech University, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Pu M; iHuman Institute, ShanghaiTech University, Shanghai, China., Korde A; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA., Jiang S; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA., Ho JH; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA., Han GW; Bridge Institute, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA., Ding K; iHuman Institute, ShanghaiTech University, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Li X; Complex Systems Division, Beijing Computational Science Research Center, Beijing, China., Liu H; Complex Systems Division, Beijing Computational Science Research Center, Beijing, China., Hanson MA; GPCR Consortium, San Marcos, CA, USA., Zhao S; iHuman Institute, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn., Bohn LM; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA. Laura.bohn@ufl.edu., Makriyannis A; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA. a.makriyannis@neu.edu.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA. a.makriyannis@neu.edu., Stevens RC; iHuman Institute, ShanghaiTech University, Shanghai, China.; Bridge Institute, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Liu ZJ; iHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. liuzhj@shanghaitech.edu.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.
Source: Nature [Nature] 2025 Oct; Vol. 646 (8085), pp. 754-758. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Crystal structures of agonist-bound human cannabinoid receptor CB<subscript>1</subscript>.
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  Data: <searchLink fieldCode="AU" term="%22Hua+T%22">Hua T</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Vemuri+K%22">Vemuri K</searchLink>; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nikas+SP%22">Nikas SP</searchLink>; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Qu+L%22">Qu L</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Pu+M%22">Pu M</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Korde+A%22">Korde A</searchLink>; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+S%22">Jiang S</searchLink>; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ho+JH%22">Ho JH</searchLink>; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.<br /><searchLink fieldCode="AU" term="%22Han+GW%22">Han GW</searchLink>; Bridge Institute, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ding+K%22">Ding K</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Complex Systems Division, Beijing Computational Science Research Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Complex Systems Division, Beijing Computational Science Research Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hanson+MA%22">Hanson MA</searchLink>; GPCR Consortium, San Marcos, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.<br /><searchLink fieldCode="AU" term="%22Bohn+LM%22">Bohn LM</searchLink>; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA. Laura.bohn@ufl.edu.<br /><searchLink fieldCode="AU" term="%22Makriyannis+A%22">Makriyannis A</searchLink>; Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA. a.makriyannis@neu.edu.; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA. a.makriyannis@neu.edu.<br /><searchLink fieldCode="AU" term="%22Stevens+RC%22">Stevens RC</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China.; Bridge Institute, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+ZJ%22">Liu ZJ</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. liuzhj@shanghaitech.edu.cn.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 Oct; Vol. 646 (8085), pp. 754-758. <i>Date of Electronic Publication: </i>2025 Aug 27.
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