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Sugammadex or Neostigmine for prevention of post-operative pulmonary complications after major abdominal or thoracic surgery: study protocol for the SINFONIA (Sugammadex for preventioN oF pOst-operative pulmonary complIcAtions) randomised controlled superiority trial.

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Title: Sugammadex or Neostigmine for prevention of post-operative pulmonary complications after major abdominal or thoracic surgery: study protocol for the SINFONIA (Sugammadex for preventioN oF pOst-operative pulmonary complIcAtions) randomised controlled superiority trial.
Authors: Silversides JA; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK. j.silversides@qub.ac.uk.; Division of Anaesthesia, Theatres and Critical Care, Belfast Health and Social Care Trust, Belfast, UK. j.silversides@qub.ac.uk., Savic L; Leeds Teaching Hospitals National Health Service Trust, Leeds, UK., Hiller L; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Hopkins A; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Booth K; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Dorey J; Patient and Public Involvement Representative, London, UK., Smithson R; Patient and Public Involvement Representative, Belfast, UK., Mason J; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Frempong S; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., May C; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Moonesinghe R; University College London, London, UK., O'Donnell CM; Division of Anaesthesia, Theatres and Critical Care, Belfast Health and Social Care Trust, Belfast, UK., Creagh-Brown B; University of Surrey, Guildford, UK., Kandiyali R; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Yeung J; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Pearse R; Queen Mary University of London, London, UK.
Corporate Authors: SINFONIA investigators
Source: Trials [Trials] 2025 Aug 28; Vol. 26 (1), pp. 319. Date of Electronic Publication: 2025 Aug 28.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sugammadex or Neostigmine for prevention of post-operative pulmonary complications after major abdominal or thoracic surgery: study protocol for the SINFONIA (Sugammadex for preventioN oF pOst-operative pulmonary complIcAtions) randomised controlled superiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Silversides+JA%22">Silversides JA</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK. j.silversides@qub.ac.uk.; Division of Anaesthesia, Theatres and Critical Care, Belfast Health and Social Care Trust, Belfast, UK. j.silversides@qub.ac.uk.<br /><searchLink fieldCode="AU" term="%22Savic+L%22">Savic L</searchLink>; Leeds Teaching Hospitals National Health Service Trust, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Hiller+L%22">Hiller L</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Hopkins+A%22">Hopkins A</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Booth+K%22">Booth K</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Dorey+J%22">Dorey J</searchLink>; Patient and Public Involvement Representative, London, UK.<br /><searchLink fieldCode="AU" term="%22Smithson+R%22">Smithson R</searchLink>; Patient and Public Involvement Representative, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Mason+J%22">Mason J</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Frempong+S%22">Frempong S</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22May+C%22">May C</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Moonesinghe+R%22">Moonesinghe R</searchLink>; University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Donnell+CM%22">O'Donnell CM</searchLink>; Division of Anaesthesia, Theatres and Critical Care, Belfast Health and Social Care Trust, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Creagh-Brown+B%22">Creagh-Brown B</searchLink>; University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22Kandiyali+R%22">Kandiyali R</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Yeung+J%22">Yeung J</searchLink>; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.<br /><searchLink fieldCode="AU" term="%22Pearse+R%22">Pearse R</searchLink>; Queen Mary University of London, London, UK.
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