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BREEZE Optional Extension Phase: Long-term safety and efficacy of treprostinil dry powder inhaler (Tyvaso DPI) in pulmonary arterial hypertension.

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Title: BREEZE Optional Extension Phase: Long-term safety and efficacy of treprostinil dry powder inhaler (Tyvaso DPI) in pulmonary arterial hypertension.
Authors: Sahay S; Division of Pulmonary, Critical Care and Sleep Medicine, Houston Methodist Hospital, 6445 Main St, Houston, TX, 77030, USA., Palevsky H; Perelman School of Medicine of the University of Pennsylvania, Penn Presbyterian Medical Center, 3737 Market St, Philadelphia, PA, 19104, USA., El-Kersh K; Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Arizona College of Medicine, 1111 East McDowell Rd, Phoenix, AZ, 85006, USA., Restrepo-Jaramillo R; University of South Florida, 2 Tampa General Cir, Tampa, FL, 33606, USA., Bajwa AA; Mayo Clinic College of Medicine & Science, Department of Pulmonary, Allergy & Sleep Medicine Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA., Desai S; John Ochsner Heart and Vascular Institute, Ochsner Medical Center, 1514 Jefferson Hwy, New Orleans, LA, 70121, USA., Joly JM; Division of Cardiovascular Disease, UAB Department of Medicine, 500 22nd St S, Birmingham, AL, 35233, USA., Spikes LA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA., Eggert MS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Sentara Cardiovascular Research Institute, 600 Gresham Dr, Norfolk, VA, 23507, USA., Johri S; Pulmonary and Critical Care Medicine, Pulmonary Associates of Richmond Inc, 6600 W Broad St, Richmond, VA, 23230, USA., Shapiro SM; Division of Cardiology, VA Greater Los Angeles Healthcare System, Division of Pulmonary Critical Care, David Geffen UCLA School of Medicine, 200 Medical Plaza, Los Angeles, CA, 90095, USA., Fisher MR; Emory University Division of Pulmonary Allergy, Critical Care and Sleep Medicine, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA., Shah TG; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd, Dallas, TX, 75390, USA., Ramani GV; Division of Cardiology, University of Maryland, 419 West Redwood St, Baltimore, MD, 21201, USA., Mehta JP; Pulmonary and Critical Care Medicine, The Cleveland Clinic, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA., Thrasher CM; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA., Deng C; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA., Smith P; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA., Broderick M; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA., Burger CD; Department of Pulmonary and Critical Care Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA. Electronic address: burger.charles@mayo.edu.
Source: Respiratory medicine [Respir Med] 2025 Nov; Vol. 248, pp. 108318. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: BREEZE Optional Extension Phase: Long-term safety and efficacy of treprostinil dry powder inhaler (Tyvaso DPI) in pulmonary arterial hypertension.
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  Data: <searchLink fieldCode="AU" term="%22Sahay+S%22">Sahay S</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Houston Methodist Hospital, 6445 Main St, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Palevsky+H%22">Palevsky H</searchLink>; Perelman School of Medicine of the University of Pennsylvania, Penn Presbyterian Medical Center, 3737 Market St, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22El-Kersh+K%22">El-Kersh K</searchLink>; Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Arizona College of Medicine, 1111 East McDowell Rd, Phoenix, AZ, 85006, USA.<br /><searchLink fieldCode="AU" term="%22Restrepo-Jaramillo+R%22">Restrepo-Jaramillo R</searchLink>; University of South Florida, 2 Tampa General Cir, Tampa, FL, 33606, USA.<br /><searchLink fieldCode="AU" term="%22Bajwa+AA%22">Bajwa AA</searchLink>; Mayo Clinic College of Medicine & Science, Department of Pulmonary, Allergy & Sleep Medicine Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Desai+S%22">Desai S</searchLink>; John Ochsner Heart and Vascular Institute, Ochsner Medical Center, 1514 Jefferson Hwy, New Orleans, LA, 70121, USA.<br /><searchLink fieldCode="AU" term="%22Joly+JM%22">Joly JM</searchLink>; Division of Cardiovascular Disease, UAB Department of Medicine, 500 22nd St S, Birmingham, AL, 35233, USA.<br /><searchLink fieldCode="AU" term="%22Spikes+LA%22">Spikes LA</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Eggert+MS%22">Eggert MS</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Sentara Cardiovascular Research Institute, 600 Gresham Dr, Norfolk, VA, 23507, USA.<br /><searchLink fieldCode="AU" term="%22Johri+S%22">Johri S</searchLink>; Pulmonary and Critical Care Medicine, Pulmonary Associates of Richmond Inc, 6600 W Broad St, Richmond, VA, 23230, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+SM%22">Shapiro SM</searchLink>; Division of Cardiology, VA Greater Los Angeles Healthcare System, Division of Pulmonary Critical Care, David Geffen UCLA School of Medicine, 200 Medical Plaza, Los Angeles, CA, 90095, USA.<br /><searchLink fieldCode="AU" term="%22Fisher+MR%22">Fisher MR</searchLink>; Emory University Division of Pulmonary Allergy, Critical Care and Sleep Medicine, 1365 Clifton Rd NE, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Shah+TG%22">Shah TG</searchLink>; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Ramani+GV%22">Ramani GV</searchLink>; Division of Cardiology, University of Maryland, 419 West Redwood St, Baltimore, MD, 21201, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+JP%22">Mehta JP</searchLink>; Pulmonary and Critical Care Medicine, The Cleveland Clinic, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA.<br /><searchLink fieldCode="AU" term="%22Thrasher+CM%22">Thrasher CM</searchLink>; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA.<br /><searchLink fieldCode="AU" term="%22Deng+C%22">Deng C</searchLink>; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA.<br /><searchLink fieldCode="AU" term="%22Smith+P%22">Smith P</searchLink>; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA.<br /><searchLink fieldCode="AU" term="%22Broderick+M%22">Broderick M</searchLink>; United Therapeutics Corporation, 55 T.W. Alexander Dr, Durham, NC, 27709, USA.<br /><searchLink fieldCode="AU" term="%22Burger+CD%22">Burger CD</searchLink>; Department of Pulmonary and Critical Care Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL, 32224, USA. Electronic address: burger.charles@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%228908438%22">Respiratory medicine</searchLink> [Respir Med] 2025 Nov; Vol. 248, pp. 108318. <i>Date of Electronic Publication: </i>2025 Aug 27.
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