Bictegravir, emtricitabine, and tenofovir alafenamide versus ritonavir-boosted protease inhibitor-based antiretroviral therapy in people with HIV and viral suppression on second-line therapy in Haiti: an open-label, randomised, non-inferiority trial.

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Title: Bictegravir, emtricitabine, and tenofovir alafenamide versus ritonavir-boosted protease inhibitor-based antiretroviral therapy in people with HIV and viral suppression on second-line therapy in Haiti: an open-label, randomised, non-inferiority trial.
Authors: Severe P; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Pierre S; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Homeus F; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Marc JB; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Trevisi L; Harvard Medical School, Boston, MA, USA., Aristhomene ML; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Bernadin GR; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Lavoile K; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Rivera V; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Duchatellier CF; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Joseph MJ; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Wu J; Analysis Group Inc, Boston, MA, USA., Rouzier V; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti; Weill Cornell Medical College, New York, NY, USA., Preval F; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Jean E; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Bernadin J; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Zion A; Analysis Group Inc, Boston, MA, USA., Pierre Louis Forestal G; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Avila-Rios S; Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico., Garcia Morales C; Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico., Zhang A; Analysis Group Inc, Boston, MA, USA., Israelski D; Gilead Sciences, Foster City, CA, USA., Apollon A; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Dumont E; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Fox E; Cornell University, Ithaca, NY, USA., Cremieux PY; Analysis Group Inc, Boston, MA, USA., Pape JW; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti; Weill Cornell Medical College, New York, NY, USA., Collins SE; Gilead Sciences, Foster City, CA, USA., Liautaud B; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti., Sax PE; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA., Koenig SP; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA. Electronic address: skoenig@bwh.harvard.edu.
Source: The lancet. HIV [Lancet HIV] 2025 Sep; Vol. 12 (9), pp. e616-e626.
Publication Type: Journal Article; Randomized Controlled Trial; Equivalence Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bictegravir, emtricitabine, and tenofovir alafenamide versus ritonavir-boosted protease inhibitor-based antiretroviral therapy in people with HIV and viral suppression on second-line therapy in Haiti: an open-label, randomised, non-inferiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Severe+P%22">Severe P</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Pierre+S%22">Pierre S</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Homeus+F%22">Homeus F</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Marc+JB%22">Marc JB</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Trevisi+L%22">Trevisi L</searchLink>; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aristhomene+ML%22">Aristhomene ML</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Bernadin+GR%22">Bernadin GR</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Lavoile+K%22">Lavoile K</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Rivera+V%22">Rivera V</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Duchatellier+CF%22">Duchatellier CF</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Joseph+MJ%22">Joseph MJ</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Analysis Group Inc, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rouzier+V%22">Rouzier V</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti; Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Preval+F%22">Preval F</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Jean+E%22">Jean E</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Bernadin+J%22">Bernadin J</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Zion+A%22">Zion A</searchLink>; Analysis Group Inc, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pierre+Louis+Forestal+G%22">Pierre Louis Forestal G</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Avila-Rios+S%22">Avila-Rios S</searchLink>; Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Garcia+Morales+C%22">Garcia Morales C</searchLink>; Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; Analysis Group Inc, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Israelski+D%22">Israelski D</searchLink>; Gilead Sciences, Foster City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Apollon+A%22">Apollon A</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Dumont+E%22">Dumont E</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Fox+E%22">Fox E</searchLink>; Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cremieux+PY%22">Cremieux PY</searchLink>; Analysis Group Inc, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pape+JW%22">Pape JW</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti; Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Collins+SE%22">Collins SE</searchLink>; Gilead Sciences, Foster City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liautaud+B%22">Liautaud B</searchLink>; Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti.<br /><searchLink fieldCode="AU" term="%22Sax+PE%22">Sax PE</searchLink>; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Koenig+SP%22">Koenig SP</searchLink>; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA. Electronic address: skoenig@bwh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101645355%22">The lancet. HIV</searchLink> [Lancet HIV] 2025 Sep; Vol. 12 (9), pp. e616-e626.
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              Text: 2025 Sep
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