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Bivalent RSV Prefusion F Protein-Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults: A Prespecified Analysis of the DAN-RSV Trial.

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Title: Bivalent RSV Prefusion F Protein-Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults: A Prespecified Analysis of the DAN-RSV Trial.
Authors: Lassen MCH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Johansen ND; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Christensen SH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Aliabadi N; Pfizer Inc, New York, New York., Skaarup KG; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Modin D; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Claggett BL; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Larsen CS; Department of Clinical Medicine-Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.; European LifeCare Group, Søborg, Denmark., Larsen L; Research Unit for Infectious Diseases, Odense University Hospital, Odense, Denmark., Wiese L; Department of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark., Dalager-Pedersen M; Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark., Lindholm MG; Department of Cardiology, Zealand University Hospital Roskilde, Roskilde, Denmark., Jensen AMR; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Dons M; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bernholm KF; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Davidovski FS; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Duus LS; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ottosen CI; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nielsen AB; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Borchsenius JH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Espersen C; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Köse G; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Fussing FH; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pareek M; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Køber L; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Solomon SD; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Jensen JUS; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Respiratory Medicine Section, Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark., Martel CJ; Statens Serum Institut, Copenhagen, Denmark., Gessner BD; Pfizer Inc, New York, New York., Schwarz C; Pfizer Inc, New York, New York., Gonzalez E; Pfizer Inc, New York, New York., Skovdal M; Pfizer Inc, New York, New York., Moulton LH; Pfizer Canada, Kirkland, Quebec, Canada., Zhang P; Pfizer Inc, New York, New York., Begier E; Pfizer Inc, New York, New York., Biering-Sørensen T; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark.
Source: JAMA [JAMA] 2025 Oct 28; Vol. 334 (16), pp. 1431-1441.
Publication Type: Clinical Trial, Phase IV; Comparative Study; Journal Article; Multicenter Study; Pragmatic Clinical Trial; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bivalent RSV Prefusion F Protein-Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults: A Prespecified Analysis of the DAN-RSV Trial.
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  Data: <searchLink fieldCode="AU" term="%22Lassen+MCH%22">Lassen MCH</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Johansen+ND%22">Johansen ND</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Christensen+SH%22">Christensen SH</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Aliabadi+N%22">Aliabadi N</searchLink>; Pfizer Inc, New York, New York.<br /><searchLink fieldCode="AU" term="%22Skaarup+KG%22">Skaarup KG</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Modin+D%22">Modin D</searchLink>; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Claggett+BL%22">Claggett BL</searchLink>; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Larsen+CS%22">Larsen CS</searchLink>; 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Steno Diabetes Center Copenhagen, Copenhagen, Denmark.
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