View in EDS

Effect of intra-articular adipose-derived mesenchymal stromal cell versus placebo injection on pain and function in patients with knee osteoarthritis: the ADIPOA2 phase 2b randomised clinical trial.

Saved in:
Bibliographic Details
Title: Effect of intra-articular adipose-derived mesenchymal stromal cell versus placebo injection on pain and function in patients with knee osteoarthritis: the ADIPOA2 phase 2b randomised clinical trial.
Authors: Pers YM; Institute for Regenerative Medicine and Biotherapy, Univ Montpellier, INSERM UMR 1183, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier, Montpellier, France. Electronic address: ym-pers@chu-montpellier.fr., Schrezenmeier H; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany., Fleury-Cappellesso S; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France., Nöth U; Department for Orthopedic and Trauma Surgery, Berlin, Germany., Rackwitz L; Department for Orthopedic and Trauma Surgery, Berlin, Germany., Ferreira R; Institute for Regenerative Medicine and Biotherapy, Univ Montpellier, INSERM UMR 1183, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier, Montpellier, France., Berenbaum F; Rheumatology Department, Sorbonne University, INSERM CRSA, Hôpital Saint-Antoine, Paris, France., Ruyssen-Witrand A; Rheumatology Centre, Toulouse University Hospital, Centre d'Investigation Clinique de Toulouse CIC1436, Inserm, Team PEPSS « Pharmacologie En Population cohorteS et biobanqueS », University of Toulouse 3, Toulouse, France., Thurlings RM; Rheumatology Department, Radboud University Medical Center, Nijmegen, The Netherlands., Addimanda O; IRCCS Istituto Ortopedico Rizzoli, Medicina e Rheumatologia, Bologna, Italy., Lisignoli G; IRCCS Istituto Ortopedico Rizzoli, Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Bologna, Italy., Ramonda R; Regenerative Medicine Institute, University of Galway, Galway, Ireland., Shannon F; Regenerative Medicine Institute, University of Galway, Galway, Ireland., Punzi L; Department of Medicine, Università Degli Studi Di Padova, Padova, Italy., Baillet A; Rheumatology Department, CHU Grenoble Alpes, Hôpital Sud, Echirolles, France., McCaskie AW; Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., McDonnell S; Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., O'Callaghan J; Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Turmezei T; Norfolk and Norwich University Hospital, Norwich, UK; University of East Anglia, Norwich, UK., Kessler DA; Department of Radiology, University of Cambridge, Cambridge, UK; Artificial Intelligence in Medicine Lab (BCN-AIM), Facultat de Matemátiques i Informática, Universitat de Barcelona, Barcelona, Spain., Lotfi R; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany., Rojewski M; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany., Duffy A; Regenerative Medicine Institute, University of Galway, Galway, Ireland., Finnerty A; Regenerative Medicine Institute, University of Galway, Galway, Ireland., Moisan A; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France., Brochot-Dechet H; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France., Aubery-Rousselet M; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France., Michon A; ECRIN, Paris, France., Bouzas-Rodriguez J; ECRIN, Paris, France., Pullig O; Department Tissue Engineering and Regenerative Medicine, University Hospital Würzburg, Würzburg, Germany., Broussous S; Research and innovation Department, CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France., Nogue E; Clinical Research and Epidemiology Unit (Public Health Department), CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France., Amico M; Clinical Research and Epidemiology Unit (Public Health Department), CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France., Picot MC; Clinical Research and Epidemiology Unit (Public Health Department), CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France; Centre de Recherche en Épidémiologie et Santé des Populations (CESP), INSERM, University Paris-Saclay, Villejuif, France., Barry F; Regenerative Medicine Institute, University of Galway, Galway, Ireland., Jorgensen C; Institute for Regenerative Medicine and Biotherapy, Univ Montpellier, INSERM UMR 1183, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier, Montpellier, France.
Corporate Authors: ADIPOA2 consortium
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2025 Dec; Vol. 84 (12), pp. 2103-2114. Date of Electronic Publication: 2025 Aug 29.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40885690
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of intra-articular adipose-derived mesenchymal stromal cell versus placebo injection on pain and function in patients with knee osteoarthritis: the ADIPOA2 phase 2b randomised clinical trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Pers+YM%22">Pers YM</searchLink>; Institute for Regenerative Medicine and Biotherapy, Univ Montpellier, INSERM UMR 1183, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier, Montpellier, France. Electronic address: ym-pers@chu-montpellier.fr.<br /><searchLink fieldCode="AU" term="%22Schrezenmeier+H%22">Schrezenmeier H</searchLink>; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Fleury-Cappellesso+S%22">Fleury-Cappellesso S</searchLink>; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France.<br /><searchLink fieldCode="AU" term="%22Nöth+U%22">Nöth U</searchLink>; Department for Orthopedic and Trauma Surgery, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rackwitz+L%22">Rackwitz L</searchLink>; Department for Orthopedic and Trauma Surgery, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ferreira+R%22">Ferreira R</searchLink>; Institute for Regenerative Medicine and Biotherapy, Univ Montpellier, INSERM UMR 1183, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Berenbaum+F%22">Berenbaum F</searchLink>; Rheumatology Department, Sorbonne University, INSERM CRSA, Hôpital Saint-Antoine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ruyssen-Witrand+A%22">Ruyssen-Witrand A</searchLink>; Rheumatology Centre, Toulouse University Hospital, Centre d'Investigation Clinique de Toulouse CIC1436, Inserm, Team PEPSS « Pharmacologie En Population cohorteS et biobanqueS », University of Toulouse 3, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Thurlings+RM%22">Thurlings RM</searchLink>; Rheumatology Department, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Addimanda+O%22">Addimanda O</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Medicina e Rheumatologia, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Lisignoli+G%22">Lisignoli G</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Ramonda+R%22">Ramonda R</searchLink>; Regenerative Medicine Institute, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Shannon+F%22">Shannon F</searchLink>; Regenerative Medicine Institute, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Punzi+L%22">Punzi L</searchLink>; Department of Medicine, Università Degli Studi Di Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Baillet+A%22">Baillet A</searchLink>; Rheumatology Department, CHU Grenoble Alpes, Hôpital Sud, Echirolles, France.<br /><searchLink fieldCode="AU" term="%22McCaskie+AW%22">McCaskie AW</searchLink>; Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McDonnell+S%22">McDonnell S</searchLink>; Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22O'Callaghan+J%22">O'Callaghan J</searchLink>; Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Turmezei+T%22">Turmezei T</searchLink>; Norfolk and Norwich University Hospital, Norwich, UK; University of East Anglia, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Kessler+DA%22">Kessler DA</searchLink>; Department of Radiology, University of Cambridge, Cambridge, UK; Artificial Intelligence in Medicine Lab (BCN-AIM), Facultat de Matemátiques i Informática, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lotfi+R%22">Lotfi R</searchLink>; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Rojewski+M%22">Rojewski M</searchLink>; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Duffy+A%22">Duffy A</searchLink>; Regenerative Medicine Institute, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Finnerty+A%22">Finnerty A</searchLink>; Regenerative Medicine Institute, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Moisan+A%22">Moisan A</searchLink>; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France.<br /><searchLink fieldCode="AU" term="%22Brochot-Dechet+H%22">Brochot-Dechet H</searchLink>; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France.<br /><searchLink fieldCode="AU" term="%22Aubery-Rousselet+M%22">Aubery-Rousselet M</searchLink>; EFS (Etablissement Français du Sang), Grenoble, St Ismier, and Toulouse Cedex 3, France.<br /><searchLink fieldCode="AU" term="%22Michon+A%22">Michon A</searchLink>; ECRIN, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bouzas-Rodriguez+J%22">Bouzas-Rodriguez J</searchLink>; ECRIN, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pullig+O%22">Pullig O</searchLink>; Department Tissue Engineering and Regenerative Medicine, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Broussous+S%22">Broussous S</searchLink>; Research and innovation Department, CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France.<br /><searchLink fieldCode="AU" term="%22Nogue+E%22">Nogue E</searchLink>; Clinical Research and Epidemiology Unit (Public Health Department), CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France.<br /><searchLink fieldCode="AU" term="%22Amico+M%22">Amico M</searchLink>; Clinical Research and Epidemiology Unit (Public Health Department), CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France.<br /><searchLink fieldCode="AU" term="%22Picot+MC%22">Picot MC</searchLink>; Clinical Research and Epidemiology Unit (Public Health Department), CHU Montpellier, Univ Montpellier, Montpellier Cedex 5, France; Centre de Recherche en Épidémiologie et Santé des Populations (CESP), INSERM, University Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Barry+F%22">Barry F</searchLink>; Regenerative Medicine Institute, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Jorgensen+C%22">Jorgensen C</searchLink>; Institute for Regenerative Medicine and Biotherapy, Univ Montpellier, INSERM UMR 1183, Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Montpellier, Montpellier, France.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22ADIPOA2+consortium%22">ADIPOA2 consortium</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220372355%22">Annals of the rheumatic diseases</searchLink> [Ann Rheum Dis] 2025 Dec; Vol. 84 (12), pp. 2103-2114. <i>Date of Electronic Publication: </i>2025 Aug 29.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372355 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-2060 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200034967%22">00034967 </searchLink><i>NLM ISO Abbreviation: </i>Ann Rheum Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40885690
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ard.2025.07.026
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2103
    Titles:
      – TitleFull: Effect of intra-articular adipose-derived mesenchymal stromal cell versus placebo injection on pain and function in patients with knee osteoarthritis: the ADIPOA2 phase 2b randomised clinical trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pers YM
      – PersonEntity:
          Name:
            NameFull: Schrezenmeier H
      – PersonEntity:
          Name:
            NameFull: Fleury-Cappellesso S
      – PersonEntity:
          Name:
            NameFull: Nöth U
      – PersonEntity:
          Name:
            NameFull: Rackwitz L
      – PersonEntity:
          Name:
            NameFull: Ferreira R
      – PersonEntity:
          Name:
            NameFull: Berenbaum F
      – PersonEntity:
          Name:
            NameFull: Ruyssen-Witrand A
      – PersonEntity:
          Name:
            NameFull: Thurlings RM
      – PersonEntity:
          Name:
            NameFull: Addimanda O
      – PersonEntity:
          Name:
            NameFull: Lisignoli G
      – PersonEntity:
          Name:
            NameFull: Ramonda R
      – PersonEntity:
          Name:
            NameFull: Shannon F
      – PersonEntity:
          Name:
            NameFull: Punzi L
      – PersonEntity:
          Name:
            NameFull: Baillet A
      – PersonEntity:
          Name:
            NameFull: McCaskie AW
      – PersonEntity:
          Name:
            NameFull: McDonnell S
      – PersonEntity:
          Name:
            NameFull: O'Callaghan J
      – PersonEntity:
          Name:
            NameFull: Turmezei T
      – PersonEntity:
          Name:
            NameFull: Kessler DA
      – PersonEntity:
          Name:
            NameFull: Lotfi R
      – PersonEntity:
          Name:
            NameFull: Rojewski M
      – PersonEntity:
          Name:
            NameFull: Duffy A
      – PersonEntity:
          Name:
            NameFull: Finnerty A
      – PersonEntity:
          Name:
            NameFull: Moisan A
      – PersonEntity:
          Name:
            NameFull: Brochot-Dechet H
      – PersonEntity:
          Name:
            NameFull: Aubery-Rousselet M
      – PersonEntity:
          Name:
            NameFull: Michon A
      – PersonEntity:
          Name:
            NameFull: Bouzas-Rodriguez J
      – PersonEntity:
          Name:
            NameFull: Pullig O
      – PersonEntity:
          Name:
            NameFull: Broussous S
      – PersonEntity:
          Name:
            NameFull: Nogue E
      – PersonEntity:
          Name:
            NameFull: Amico M
      – PersonEntity:
          Name:
            NameFull: Picot MC
      – PersonEntity:
          Name:
            NameFull: Barry F
      – PersonEntity:
          Name:
            NameFull: Jorgensen C
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: 2025 Dec
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1468-2060
          Numbering:
            – Type: volume
              Value: 84
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Annals of the rheumatic diseases
              Type: main
ResultId 1