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Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/wnt/ β-catenin, and related ferroptosis pathways.

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Title: Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/wnt/ β-catenin, and related ferroptosis pathways.
Authors: Hamdy A; Pharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University, 11785 Cairo, Egypt., Sayed RH; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt; Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Giza, Egypt., El-Yamany MF; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt., Helal GK; Pharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University, 11785 Cairo, Egypt., Fahmy MI; Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), P.O. Box 77, Giza, Egypt. Electronic address: mohamed.aljawaly@must.edu.eg.
Source: Life sciences [Life Sci] 2025 Nov 01; Vol. 380, pp. 123941. Date of Electronic Publication: 2025 Aug 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/wnt/ β-catenin, and related ferroptosis pathways.
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  Data: <searchLink fieldCode="AU" term="%22Hamdy+A%22">Hamdy A</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University, 11785 Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Sayed+RH%22">Sayed RH</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt; Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Yamany+MF%22">El-Yamany MF</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Helal+GK%22">Helal GK</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University, 11785 Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Fahmy+MI%22">Fahmy MI</searchLink>; Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), P.O. Box 77, Giza, Egypt. Electronic address: mohamed.aljawaly@must.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%220375521%22">Life sciences</searchLink> [Life Sci] 2025 Nov 01; Vol. 380, pp. 123941. <i>Date of Electronic Publication: </i>2025 Aug 30.
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      – TitleFull: Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/wnt/ β-catenin, and related ferroptosis pathways.
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