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Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model.

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Title: Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model.
Authors: Wood JI; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom., Dulewicz M; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden., Szadziewska A; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Weiner S; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom., Ge J; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Stringer K; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom., Desai S; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom., Fenson L; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Piotrowska D; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Brinkmalm G; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal Hospital, House V, Mölndal, Sweden., Koutarapu S; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Hajar HB; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom., Blennow K; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal Hospital, House V, Mölndal, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P. R. China., Zetterberg H; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal Hospital, House V, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, PR China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Cummings DM; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom., Savas JN; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Edwards FA; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom., Hanrieder J; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden. jh@gu.se.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden. jh@gu.se.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom. jh@gu.se.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom. jh@gu.se.
Source: Nature communications [Nat Commun] 2025 Sep 01; Vol. 16 (1), pp. 8170. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Wood+JI%22">Wood JI</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dulewicz+M%22">Dulewicz M</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Szadziewska+A%22">Szadziewska A</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Weiner+S%22">Weiner S</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ge+J%22">Ge J</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Stringer+K%22">Stringer K</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Desai+S%22">Desai S</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fenson+L%22">Fenson L</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Piotrowska+D%22">Piotrowska D</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Brinkmalm+G%22">Brinkmalm G</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal Hospital, House V, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Koutarapu+S%22">Koutarapu S</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Hajar+HB%22">Hajar HB</searchLink>; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal Hospital, House V, Mölndal, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, P. 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China.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal Hospital, House V, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, PR China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Cummings+DM%22">Cummings DM</searchLink>; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Savas+JN%22">Savas JN</searchLink>; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+FA%22">Edwards FA</searchLink>; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hanrieder+J%22">Hanrieder J</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden. jh@gu.se.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden. jh@gu.se.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom. jh@gu.se.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, Queens Square, London, United Kingdom. jh@gu.se.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Sep 01; Vol. 16 (1), pp. 8170. <i>Date of Electronic Publication: </i>2025 Sep 01.
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