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Hyaluronidase-enhanced subcutaneous delivery of bNAbs: a phase 1 randomized controlled clinical trial in HIV-uninfected women.

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Title: Hyaluronidase-enhanced subcutaneous delivery of bNAbs: a phase 1 randomized controlled clinical trial in HIV-uninfected women.
Authors: Mahomed S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. Sharana.Mahomed@caprisa.org.; Department of Medical Microbiology, School of Laboratory Medicine, University of KwaZulu-Natal, Durban, South Africa. Sharana.Mahomed@caprisa.org., Osman F; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa., Beliveau M; Certara, Montreal, QC, Canada., Heredia-Ortiz R; Certara, Montreal, QC, Canada., Carlton K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wang J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Mughal M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Low K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Narpala S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Castro M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Serebryannyy L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Karim QA; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Source: Nature communications [Nat Commun] 2025 Sep 01; Vol. 16 (1), pp. 8177. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hyaluronidase-enhanced subcutaneous delivery of bNAbs: a phase 1 randomized controlled clinical trial in HIV-uninfected women.
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  Data: <searchLink fieldCode="AU" term="%22Mahomed+S%22">Mahomed S</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. Sharana.Mahomed@caprisa.org.; Department of Medical Microbiology, School of Laboratory Medicine, University of KwaZulu-Natal, Durban, South Africa. Sharana.Mahomed@caprisa.org.<br /><searchLink fieldCode="AU" term="%22Osman+F%22">Osman F</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Beliveau+M%22">Beliveau M</searchLink>; Certara, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Heredia-Ortiz+R%22">Heredia-Ortiz R</searchLink>; Certara, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Carlton+K%22">Carlton K</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mughal+M%22">Mughal M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Low+K%22">Low K</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Narpala+S%22">Narpala S</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lin+BC%22">Lin BC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Castro+M%22">Castro M</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Serebryannyy+L%22">Serebryannyy L</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Koup+RA%22">Koup RA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Karim+QA%22">Karim QA</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Abdool+Karim+SS%22">Abdool Karim SS</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
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