Genome mining of Streptomyces bambergiensis AC-800 unravels the biosynthetic gene cluster for inhibitors of prolyl hydroxylase fibrostatins.

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Title: Genome mining of Streptomyces bambergiensis AC-800 unravels the biosynthetic gene cluster for inhibitors of prolyl hydroxylase fibrostatins.
Authors: Guerrero Garzón JF; Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna, 1090, Austria., Zehl M; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, 1090, Austria., Schneider O; Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna, 1090, Austria., Marquez IT; Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna, 1090, Austria., Rückert-Reed C; Medical School OWL, Bielefeld University, 33615, Bielefeld, Germany.; Technology Platform Genomics, Center for Biotechnology (CeBiTec), Bielefeld University, 33615, Bielefeld, Germany., Kalinowski J; Technology Platform Genomics, Center for Biotechnology (CeBiTec), Bielefeld University, 33615, Bielefeld, Germany., Zotchev SB; Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Vienna, 1090, Austria. sergey.zotchev@univie.ac.at.
Source: Scientific reports [Sci Rep] 2025 Sep 01; Vol. 15 (1), pp. 32142. Date of Electronic Publication: 2025 Sep 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-025-17585-y