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Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.

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Title: Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.
Authors: Wilhelmsen K; BioAge Labs , Emeryville, CA, USA., Deshpande A; BioAge Labs , Emeryville, CA, USA., Tronnes S; BioAge Labs , Emeryville, CA, USA., Mahanta M; BioAge Labs , Emeryville, CA, USA., Banicki M; BioAge Labs , Emeryville, CA, USA., Cochran M; BioAge Labs , Emeryville, CA, USA., Cowdin S; BioAge Labs , Emeryville, CA, USA., Fortney K; BioAge Labs , Emeryville, CA, USA., Hartman G; BioAge Labs , Emeryville, CA, USA., Hughes RE; BioAge Labs , Emeryville, CA, USA., Montgomery R; BioAge Labs , Emeryville, CA, USA., Portillo CP; BioAge Labs , Emeryville, CA, USA., Rubin P; BioAge Labs , Emeryville, CA, USA., Salazar T; BioAge Labs , Emeryville, CA, USA., Wang Y; BioAge Labs , Emeryville, CA, USA., Yan S; BioAge Labs , Emeryville, CA, USA., Morgan BA; HitGen Pharmaceuticals Inc. , Houston, TX, USA., Duisembekova A; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France., Riou R; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France., Marleaux M; Institute of Structural Biology, University of Bonn , Bonn, Germany., Hochheiser IV; Institute of Structural Biology, University of Bonn , Bonn, Germany., Buthmann H; Institute of Structural Biology, University of Bonn , Bonn, Germany., Ferber D; Institute of Structural Biology, University of Bonn , Bonn, Germany., Torp J; Institute of Structural Biology, University of Bonn , Bonn, Germany., Wang W; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., Cranston M; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., McKee CM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., Mawhinney TJ; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., McKay EC; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK., Eroglu FK; Department of Innate Immunity, Institute of Immunology, Tübingen, Germany.; Department of Pediatrics I, Pediatric Rheumatology and Autoinflammation Reference Center, University Hospital Tübingen, Tübingen, Germany., Kümmerle-Deschner J; Department of Pediatrics I, Pediatric Rheumatology and Autoinflammation Reference Center, University Hospital Tübingen, Tübingen, Germany., Weber ANR; Department of Innate Immunity, Institute of Immunology, Tübingen, Germany.; Cluster of Excellence 2180 'Image-guided and Functionally Instructed Tumor Therapies' and Cluster of Excellence 2124 'Controlling Microbes to Fight Infection', University of Tübingen , Tübingen, Germany., Py BF; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France., Geyer M; Institute of Structural Biology, University of Bonn , Bonn, Germany., Coll RC; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.
Source: The Journal of experimental medicine [J Exp Med] 2025 Nov 03; Vol. 222 (11). Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.
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  Data: <searchLink fieldCode="AU" term="%22Wilhelmsen+K%22">Wilhelmsen K</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Deshpande+A%22">Deshpande A</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tronnes+S%22">Tronnes S</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mahanta+M%22">Mahanta M</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Banicki+M%22">Banicki M</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cochran+M%22">Cochran M</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cowdin+S%22">Cowdin S</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fortney+K%22">Fortney K</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hartman+G%22">Hartman G</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+RE%22">Hughes RE</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Montgomery+R%22">Montgomery R</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Portillo+CP%22">Portillo CP</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rubin+P%22">Rubin P</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Salazar+T%22">Salazar T</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yan+S%22">Yan S</searchLink>; BioAge Labs , Emeryville, CA, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+BA%22">Morgan BA</searchLink>; HitGen Pharmaceuticals Inc. , Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Duisembekova+A%22">Duisembekova A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France.<br /><searchLink fieldCode="AU" term="%22Riou+R%22">Riou R</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France.<br /><searchLink fieldCode="AU" term="%22Marleaux+M%22">Marleaux M</searchLink>; Institute of Structural Biology, University of Bonn , Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hochheiser+IV%22">Hochheiser IV</searchLink>; Institute of Structural Biology, University of Bonn , Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Buthmann+H%22">Buthmann H</searchLink>; Institute of Structural Biology, University of Bonn , Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Ferber+D%22">Ferber D</searchLink>; Institute of Structural Biology, University of Bonn , Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Torp+J%22">Torp J</searchLink>; Institute of Structural Biology, University of Bonn , Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Cranston+M%22">Cranston M</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McKee+CM%22">McKee CM</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Mawhinney+TJ%22">Mawhinney TJ</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McKay+EC%22">McKay EC</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Eroglu+FK%22">Eroglu FK</searchLink>; Department of Innate Immunity, Institute of Immunology, Tübingen, Germany.; Department of Pediatrics I, Pediatric Rheumatology and Autoinflammation Reference Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kümmerle-Deschner+J%22">Kümmerle-Deschner J</searchLink>; Department of Pediatrics I, Pediatric Rheumatology and Autoinflammation Reference Center, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+ANR%22">Weber ANR</searchLink>; Department of Innate Immunity, Institute of Immunology, Tübingen, Germany.; Cluster of Excellence 2180 'Image-guided and Functionally Instructed Tumor Therapies' and Cluster of Excellence 2124 'Controlling Microbes to Fight Infection', University of Tübingen , Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Py+BF%22">Py BF</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon , Lyon, France.<br /><searchLink fieldCode="AU" term="%22Geyer+M%22">Geyer M</searchLink>; Institute of Structural Biology, University of Bonn , Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Coll+RC%22">Coll RC</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast , Belfast, UK.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2025 Nov 03; Vol. 222 (11). <i>Date of Electronic Publication: </i>2025 Sep 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
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