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PRIME 2.0: Proposed Requirements for Cardiovascular Imaging-Related Multimodal-AI Evaluation: An Updated Checklist.

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Title: PRIME 2.0: Proposed Requirements for Cardiovascular Imaging-Related Multimodal-AI Evaluation: An Updated Checklist.
Authors: Kagiyama N; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; AI Incubation Farm, Juntendo University Faculty of Medicine, Tokyo, Japan., Tokodi M; Heart and Vascular Center, Semmelweis University, Budapest, Hungary; Department of Experimental Cardiology and Surgical Techniques, Semmelweis University, Budapest, Hungary., Hathaway QA; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Arnaout R; Department of Medicine, Radiology, and Pediatrics, University of California, San Francisco, California, USA; Bakar Institute, University of California, San Francisco, California, USA; UCSF-UC Berkeley Joint Program in Computational Precision Health, San Francisco, California, USA., Davies R; Institute of Cardiovascular Science, University College London, London, United Kingdom., Dey D; Cedars-Sinai Medical Center, Biomedical Sciences, Los Angeles, California, USA., Duchateau N; Universite Claude Bernard Lyon 1, INSA-Lyon, CREATIS lab, CNRS UMR5220, Inserm U1294, Villeurbanne, France; Institut Universitaire de France (IUF), Paris, France., Fraser AG; School of Medicine, Cardiff University, Cardiff, United Kingdom., Goto S; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Tokai University School of Medicine, Japan., Jamthikar AD; Division of Cardiovascular Diseases and Hypertension, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA., Lam CSP; National Heart Centre Singapore and Duke-National University of Singapore, Singapore., Oikonomou EK; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Ouyang D; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Division of Research, Kaiser Permanente Northern California, Pleasanton, California, USA., Pandey A; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Poterucha TJ; Mayo Clinic, Division of Echocardiography and Cardiac Imaging, Department of Cardiology, Rochester, Minnesota, USA; Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA., Raisi-Estabragh Z; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom., Strom JB; Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA., Zhang Q; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom., Yanamala N; Division of Cardiovascular Diseases and Hypertension, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA., Sengupta PP; Division of Cardiovascular Diseases and Hypertension, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. Electronic address: partho.sengupta@rutgers.edu.
Source: JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2026 Feb; Vol. 19 (2), pp. 225-251. Date of Electronic Publication: 2025 Aug 27.
Publication Type: Journal Article; Practice Guideline; Review
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101467978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7591 (Electronic) Linking ISSN: 18767591 NLM ISO Abbreviation: JACC Cardiovasc Imaging Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kagiyama+N%22">Kagiyama N</searchLink>; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; AI Incubation Farm, Juntendo University Faculty of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tokodi+M%22">Tokodi M</searchLink>; Heart and Vascular Center, Semmelweis University, Budapest, Hungary; Department of Experimental Cardiology and Surgical Techniques, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Hathaway+QA%22">Hathaway QA</searchLink>; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Arnaout+R%22">Arnaout R</searchLink>; Department of Medicine, Radiology, and Pediatrics, University of California, San Francisco, California, USA; Bakar Institute, University of California, San Francisco, California, USA; UCSF-UC Berkeley Joint Program in Computational Precision Health, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Davies+R%22">Davies R</searchLink>; Institute of Cardiovascular Science, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dey+D%22">Dey D</searchLink>; Cedars-Sinai Medical Center, Biomedical Sciences, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Duchateau+N%22">Duchateau N</searchLink>; Universite Claude Bernard Lyon 1, INSA-Lyon, CREATIS lab, CNRS UMR5220, Inserm U1294, Villeurbanne, France; Institut Universitaire de France (IUF), Paris, France.<br /><searchLink fieldCode="AU" term="%22Fraser+AG%22">Fraser AG</searchLink>; School of Medicine, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Goto+S%22">Goto S</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Tokai University School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Jamthikar+AD%22">Jamthikar AD</searchLink>; Division of Cardiovascular Diseases and Hypertension, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Lam+CSP%22">Lam CSP</searchLink>; National Heart Centre Singapore and Duke-National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Oikonomou+EK%22">Oikonomou EK</searchLink>; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Ouyang+D%22">Ouyang D</searchLink>; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Division of Research, Kaiser Permanente Northern California, Pleasanton, California, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+A%22">Pandey A</searchLink>; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Poterucha+TJ%22">Poterucha TJ</searchLink>; Mayo Clinic, Division of Echocardiography and Cardiac Imaging, Department of Cardiology, Rochester, Minnesota, USA; Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Raisi-Estabragh+Z%22">Raisi-Estabragh Z</searchLink>; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Strom+JB%22">Strom JB</searchLink>; Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yanamala+N%22">Yanamala N</searchLink>; Division of Cardiovascular Diseases and Hypertension, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Sengupta+PP%22">Sengupta PP</searchLink>; Division of Cardiovascular Diseases and Hypertension, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. Electronic address: partho.sengupta@rutgers.edu.
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  Data: <searchLink fieldCode="JN" term="%22101467978%22">JACC. Cardiovascular imaging</searchLink> [JACC Cardiovasc Imaging] 2026 Feb; Vol. 19 (2), pp. 225-251. <i>Date of Electronic Publication: </i>2025 Aug 27.
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