View in EDS

EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.

Saved in:
Bibliographic Details
Title: EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Authors: German B; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Morel KL; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia., Noel T; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA., Boufaied N; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada., Burkhart DL; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Chen S; West China School of Public Health, West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China., Dezem F; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA., Qui X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Long HW; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., DiFazio S; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Baca S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Shafi AA; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Freedman ML; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Beltran H; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Sweeney CJ; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Brown M; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA., Plummer JT; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA., Knott SRV; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles CA, USA., Labbe DP; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada., Ellis L; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Source: Research square [Res Sq] 2025 Aug 21. Date of Electronic Publication: 2025 Aug 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40894056
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22German+B%22">German B</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Morel+KL%22">Morel KL</searchLink>; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia.<br /><searchLink fieldCode="AU" term="%22Noel+T%22">Noel T</searchLink>; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA.<br /><searchLink fieldCode="AU" term="%22Boufaied+N%22">Boufaied N</searchLink>; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Burkhart+DL%22">Burkhart DL</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; West China School of Public Health, West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Dezem+F%22">Dezem F</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA.<br /><searchLink fieldCode="AU" term="%22Qui+X%22">Qui X</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Long+HW%22">Long HW</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22DiFazio+S%22">DiFazio S</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Baca+S%22">Baca S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Shafi+AA%22">Shafi AA</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Freedman+ML%22">Freedman ML</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Beltran+H%22">Beltran H</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Sweeney+CJ%22">Sweeney CJ</searchLink>; South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide SA, Australia.<br /><searchLink fieldCode="AU" term="%22He+HH%22">He HH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Brown+M%22">Brown M</searchLink>; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston MA, USA.<br /><searchLink fieldCode="AU" term="%22Plummer+JT%22">Plummer JT</searchLink>; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis TN, USA.<br /><searchLink fieldCode="AU" term="%22Knott+SRV%22">Knott SRV</searchLink>; Cedars-Sinai Center for Bioinformatics and Functional Genomics, Los Angeles CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles CA, USA.<br /><searchLink fieldCode="AU" term="%22Labbe+DP%22">Labbe DP</searchLink>; Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ellis+L%22">Ellis L</searchLink>; Center for Prostate Disease Research, Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101768035%22">Research square</searchLink> [Res Sq] 2025 Aug 21. <i>Date of Electronic Publication: </i>2025 Aug 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Preprint
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101768035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2693-5015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226935015%22">26935015 </searchLink><i>NLM ISO Abbreviation: </i>Res Sq <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40894056
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.21203/rs.3.rs-7360528/v1
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: German B
      – PersonEntity:
          Name:
            NameFull: Morel KL
      – PersonEntity:
          Name:
            NameFull: Noel T
      – PersonEntity:
          Name:
            NameFull: Boufaied N
      – PersonEntity:
          Name:
            NameFull: Burkhart DL
      – PersonEntity:
          Name:
            NameFull: Chen S
      – PersonEntity:
          Name:
            NameFull: Dezem F
      – PersonEntity:
          Name:
            NameFull: Qui X
      – PersonEntity:
          Name:
            NameFull: Long HW
      – PersonEntity:
          Name:
            NameFull: DiFazio S
      – PersonEntity:
          Name:
            NameFull: Baca S
      – PersonEntity:
          Name:
            NameFull: Shafi AA
      – PersonEntity:
          Name:
            NameFull: Freedman ML
      – PersonEntity:
          Name:
            NameFull: Beltran H
      – PersonEntity:
          Name:
            NameFull: Sweeney CJ
      – PersonEntity:
          Name:
            NameFull: He HH
      – PersonEntity:
          Name:
            NameFull: Brown M
      – PersonEntity:
          Name:
            NameFull: Plummer JT
      – PersonEntity:
          Name:
            NameFull: Knott SRV
      – PersonEntity:
          Name:
            NameFull: Labbe DP
      – PersonEntity:
          Name:
            NameFull: Ellis L
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 08
              Text: 2025 Aug 21
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2693-5015
          Titles:
            – TitleFull: Research square
              Type: main
ResultId 1