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Genetic determinants of testicular sperm extraction outcomes: insights from a large multicentre study of men with non-obstructive azoospermia.

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Title: Genetic determinants of testicular sperm extraction outcomes: insights from a large multicentre study of men with non-obstructive azoospermia.
Authors: Riera-Escamilla A; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.; Division of Genetics, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA., Arafa MM; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Clinical Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Andrology, Cairo University, Cairo, Egypt., Farnetani G; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy., Xavier MJ; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK., Oud MS; Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboudumc, Nijmegen, The Netherlands., Majzoub AA; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Clinical Urology, Weill Cornell Medicine-Qatar, Doha, Qatar., Ramos L; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands., Abrardo C; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain., Spinelli M; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy., Moreno-Mendoza D; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.; Department of Urology, Hospital Francisco Grande Covián, Arriondas, Asturias, Spain., Defazio G; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.; Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, Bari, Italy., Ars E; Molecular Genetic Laboratory Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain., Pybus M; Molecular Genetic Laboratory Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain., Sánchez Curbelo JR; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain., Elbardisi HT; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Clinical Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Clinical Urology, College of Medicine, Qatar University, Doha, Qatar., Nawaz S; Laboratory of Reproductive Biology, Sidra Medicine, Doha, Qatar.; Laboratory of Genomic Medicine, Sidra Medicine, Doha, Qatar., Syed N; Laboratory of Genomic Medicine, Sidra Medicine, Doha, Qatar., Ruiz-Castané E; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain., van der Heijden GW; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands., Fakhro KA; Laboratory of Genomic Medicine, Sidra Medicine, Doha, Qatar.; College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Doha, Qatar.; Department of Genetic Medicine, Weill Cornell Medicine, (WCM-Q), Doha, Qatar., Veltman JA; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK.; Institute of Genetics and Cancer, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK., Krausz C; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Source: Human reproduction open [Hum Reprod Open] 2025 Aug 29; Vol. 2025 (3), pp. hoaf049. Date of Electronic Publication: 2025 Aug 29 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101722764 Publication Model: eCollection Cited Medium: Internet ISSN: 2399-3529 (Electronic) Linking ISSN: 23993529 NLM ISO Abbreviation: Hum Reprod Open Subsets: PubMed not MEDLINE
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  Data: Genetic determinants of testicular sperm extraction outcomes: insights from a large multicentre study of men with non-obstructive azoospermia.
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  Data: <searchLink fieldCode="AU" term="%22Riera-Escamilla+A%22">Riera-Escamilla A</searchLink>; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.; Division of Genetics, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.<br /><searchLink fieldCode="AU" term="%22Arafa+MM%22">Arafa MM</searchLink>; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Clinical Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Andrology, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Farnetani+G%22">Farnetani G</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Xavier+MJ%22">Xavier MJ</searchLink>; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Oud+MS%22">Oud MS</searchLink>; Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboudumc, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Majzoub+AA%22">Majzoub AA</searchLink>; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Clinical Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Ramos+L%22">Ramos L</searchLink>; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Abrardo+C%22">Abrardo C</searchLink>; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Spinelli+M%22">Spinelli M</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Moreno-Mendoza+D%22">Moreno-Mendoza D</searchLink>; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.; Department of Urology, Hospital Francisco Grande Covián, Arriondas, Asturias, Spain.<br /><searchLink fieldCode="AU" term="%22Defazio+G%22">Defazio G</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.; Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Ars+E%22">Ars E</searchLink>; Molecular Genetic Laboratory Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Pybus+M%22">Pybus M</searchLink>; Molecular Genetic Laboratory Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez+Curbelo+JR%22">Sánchez Curbelo JR</searchLink>; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Elbardisi+HT%22">Elbardisi HT</searchLink>; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Clinical Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Clinical Urology, College of Medicine, Qatar University, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Nawaz+S%22">Nawaz S</searchLink>; Laboratory of Reproductive Biology, Sidra Medicine, Doha, Qatar.; Laboratory of Genomic Medicine, Sidra Medicine, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Syed+N%22">Syed N</searchLink>; Laboratory of Genomic Medicine, Sidra Medicine, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Ruiz-Castané+E%22">Ruiz-Castané E</searchLink>; Department of Andrology, Fundació Puigvert, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22van+der+Heijden+GW%22">van der Heijden GW</searchLink>; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Fakhro+KA%22">Fakhro KA</searchLink>; Laboratory of Genomic Medicine, Sidra Medicine, Doha, Qatar.; College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Doha, Qatar.; Department of Genetic Medicine, Weill Cornell Medicine, (WCM-Q), Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Veltman+JA%22">Veltman JA</searchLink>; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK.; Institute of Genetics and Cancer, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Krausz+C%22">Krausz C</searchLink>; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
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