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An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer.

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Title: An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer.
Authors: McAndrews KM; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Paradiso F; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Stalnecker CA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Chellakkan BS; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Thege FI; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Peng DH; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Moreno Diaz BA; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sugimoto H; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Patel SI; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Mahadevan KK; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kirtley ML; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wills D; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sockwell AM; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Fonseca ALF; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Liu Y; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Rajapakshe KI; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Yee NG; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Tran PT; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Omar HA; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Tedeschi A; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Schischlik-Siegl F; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Boghossian AS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ronan MM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rudolph D; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Aichinger M; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Ebner F; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Artemov AV; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Lipp J; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Pisarsky L; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Herrmann VL; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach 88937, Germany., Park J; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach 88937, Germany., Rippmann JF; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach 88937, Germany., Schaaf O; Boehringer Ingelheim RCV GmbH & Co KG, Vienna 1121, Austria., Chandler V; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Williams M; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Deckard CE; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wang L; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Der CJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Vellano C; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Guerrero PA; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Heffernan TP; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kalluri R; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Rice University, Houston, TX 77005, USA.; Baylor College of Medicine, Houston, TX 77030, USA.; University of Texas Medical Branch, Galveston, TX 77555, USA., Maitra A; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Sep 03; Vol. 17 (814), pp. eadt5511. Date of Electronic Publication: 2025 Sep 03.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer.
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University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kalluri+R%22">Kalluri R</searchLink>; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Rice University, Houston, TX 77005, USA.; Baylor College of Medicine, Houston, TX 77030, USA.; University of Texas Medical Branch, Galveston, TX 77555, USA.<br /><searchLink fieldCode="AU" term="%22Maitra+A%22">Maitra A</searchLink>; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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