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Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach.

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Title: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach.
Authors: Wang E; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo; Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., Henley W; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom; Department of Health and Community Sciences, University of Exeter Medical School, Exeter, United Kingdom., Larenas-Linnemann D; Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Mexico City, Mexico., Bulathsinhala L; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom., Tran TN; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Md., Wechsler ME; Department of Medicine, NJH Cohen Family Asthma Institute, National Jewish Health, Denver, Colo., Aaron SD; The Ottawa Hospital Research Institute, Ottawa, ON, Canada., Al-Ahmad M; Microbiology Department, College of Medicine, Kuwait University, Kuwait City, Kuwait; Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait., Al-Lehebi R; Department of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Altraja A; Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia., Barker P; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Md., Beastall A; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom., Belevskiy AS; Department of Pulmonology, N.I. Pirogov Russian State National Research Medical University, Moscow, Russian Federation., Bergeron C; Centre for Lung Health, Vancouver General Hospital, Vancouver, BC, Canada; Department of Medicine, Centre for Lung Health, The University of British Columbia, Vancouver, BC, Canada., Bjermer L; Respiratory Medicine and Allergology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden., Björnsdóttir US; Department of Allergy and Respiratory Medicine, University Hospital, Reykjavik, Iceland., Bosnic-Anticevich SZ; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Sydney, NSW, Australia., Bourdin A; PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France., Brusselle GG; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Departments of Epidemiology and Respiratory Medicine, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Busby J; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom., Canonica GW; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy., Carter V; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom., Chapman KR; University of Toronto, Toronto, ON, Canada., Chapman N; Saint Joseph Hospital, Denver, Colo; National Jewish Health, Denver, Colo., Christoff GC; Bulgarian Alliance for Clinical and Translational Allergy, Sofia, Bulgaria., Cosio BG; Son Espases University Hospital-IdISBa-Ciberes, Mallorca, Spain., Costello RW; Department of Respiratory Medicine, Clinical Research Centre, Smurfit Building Beaumont Hospital, RCSI, Dublin, Ireland., Fingleton J; Capital and Coast District Health Board, Wellington, New Zealand., Fonseca JA; CINTESIS@RISE (Center for Health Technology and Services Research at Health Research Network), MEDCIDS (Departamento Medicina da Comunidade, Informação e Decisão em Saúde/Department of Community Medicine, Information and Health Decisions), Faculty of Medicine of the University of Porto, Porto, Portugal., Gaga M; 1st Respiratory Medicine Department, Hygeia Hospital, Athens, Greece., Gibson PG; Australian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, NSW, Australia; Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton Heights, NSW, Australia., Hansen S; Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Heaney LG; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom., Heffler E; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy., Hew M; Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, VIC, Australia; Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Horiguchi T; Toyota Regional Medical Center, Nishiyamacho, Toyota, Japan., Hoyte F; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo., Hubbard RB; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom; Respiratory Medicine at the School of Medicine, University of Nottingham, Nottingham, United Kingdom., Iwanaga T; Kindai University Hospital, Osakasayama, Japan., Jackson DJ; Guy's Severe Asthma Centre, School of Immunology & Microbial Sciences, King's College, London, United Kingdom., Katial R; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo., Koh MS; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore., Kostikas K; Respiratory Medicine Department, University of Ioannina, Ioannina, Greece., Kuna P; Division of Internal Medicine Asthma and Allergy, Medical University of Lodz, Lodz, Poland., Lehmann S; Section of Thoracic Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway., Lehtimäki L; Allergy Centre, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Louis R; Department Pneumology CHU Liege, GIGA I(3) Research Group, University of Liege, Liege, Belgium., Lúdvíksdóttir D; Department of Respiratory Medicine, Landspitali University Hospital Reykjavik Iceland, University of Iceland, Reykjavik, Iceland., Lugogo N; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Mich., Mahboub B; Rashid Hospital, Dubai Health Authority (DHA), Dubai, United Arab Emirates; Dubai Academic and Health Corporation, Dubai, United Arab Emirates., Martin N; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Md; Department of Respiratory Medicine, University of Leicester, Leicester, United Kingdom., Máspero J; Clinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina; University Career of Specialists in Allergy and Clinical Immunology at the Buenos Aires University School of Medicine, Buenos Aires, Argentina., Menzies-Gow AN; Lung Division, Royal Brompton & Harefield Hospital, London, United Kingdom; AstraZeneca, Cambridge, United Kingdom., Mohan A; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Mich., Murray RB; Optimum Patient Care Global, Cambridge, United Kingdom., Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan., Papadopoulos NG; Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece., Papaioannou AI; 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, Greece., Patel PH; Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom., Perez-de-Llano L; Pneumology Service, Lucus Augusti University Hospital, EOXI Lugo, Monforte, Cervo, Spain., Perng DW; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Peters MJ; Department of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia; Faculty of Medicine, Health and Health Sciences, Macquarie University, Sydney, NSW, Australia., Pfeffer PE; Department of Respiratory Medicine, Barts Health NHS Trust, London, United Kingdom; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Pitrez PM; Pulmonology Division, Hospital Santa Casa de Porto Alegre, Porto Alegre, Brazil., Pleasants RA; Marsico Lung Institute, University of North Carolina, Chapel Hill, NC., Popov TA; University Hospital St. Ivan Rilski, Sofia, Bulgaria., Porsbjerg CM; Department of Respiratory Medicine and Infectious Diseases, Research Unit, Bispebjerg Hospital, Copenhagen, Denmark., Puggioni F; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy., Quinton A; AstraZeneca, Cambridge, United Kingdom., Rhee CK; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, South Korea., Sadatsafavi M; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, the University of British Columbia, Vancouver, BC, Canada., Salvi S; Pulmocare Research and Education Foundation, Pune, India., Scioscia G; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy., Sheu CC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Sirena C; Severe Asthma Network Italy (SANI), Milano, Italy., Taillé C; Department of Respiratory Diseases, Bichat Hospital, AP-HP, Université Paris Cité, Paris, France., Taube C; Department of Pulmonary Medicine, University Medical Center Essen-Ruhrlandklinik, Essen, Germany., Torres-Duque CA; CINEUMO, Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia; Universidad de La Sabana, Chia, Colombia., Tsai MJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Tunsäter A; Respiratory Medicine and Allergology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden., Ulrik CS; Department of Respiratory Medicine, Copenhagen University Hospital, Hvidovre, Denmark., Price DB; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address: dprice@opri.sg.
Source: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2025 Dec; Vol. 13 (12), pp. 3296-3315. Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101597220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2201 (Electronic) NLM ISO Abbreviation: J Allergy Clin Immunol Pract Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach.
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  Data: <searchLink fieldCode="AU" term="%22Wang+E%22">Wang E</searchLink>; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo; Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo.<br /><searchLink fieldCode="AU" term="%22Henley+W%22">Henley W</searchLink>; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom; Department of Health and Community Sciences, University of Exeter Medical School, Exeter, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Larenas-Linnemann+D%22">Larenas-Linnemann D</searchLink>; Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Bulathsinhala+L%22">Bulathsinhala L</searchLink>; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tran+TN%22">Tran TN</searchLink>; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Md.<br /><searchLink fieldCode="AU" term="%22Wechsler+ME%22">Wechsler ME</searchLink>; Department of Medicine, NJH Cohen Family Asthma Institute, National Jewish Health, Denver, Colo.<br /><searchLink fieldCode="AU" term="%22Aaron+SD%22">Aaron SD</searchLink>; The Ottawa Hospital Research Institute, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Al-Ahmad+M%22">Al-Ahmad M</searchLink>; Microbiology Department, College of Medicine, Kuwait University, Kuwait City, Kuwait; Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait.<br /><searchLink fieldCode="AU" term="%22Al-Lehebi+R%22">Al-Lehebi R</searchLink>; Department of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Altraja+A%22">Altraja A</searchLink>; Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Barker+P%22">Barker P</searchLink>; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Md.<br /><searchLink fieldCode="AU" term="%22Beastall+A%22">Beastall A</searchLink>; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Belevskiy+AS%22">Belevskiy AS</searchLink>; Department of Pulmonology, N.I. Pirogov Russian State National Research Medical University, Moscow, Russian Federation.<br /><searchLink fieldCode="AU" term="%22Bergeron+C%22">Bergeron C</searchLink>; Centre for Lung Health, Vancouver General Hospital, Vancouver, BC, Canada; Department of Medicine, Centre for Lung Health, The University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Bjermer+L%22">Bjermer L</searchLink>; Respiratory Medicine and Allergology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Björnsdóttir+US%22">Björnsdóttir US</searchLink>; Department of Allergy and Respiratory Medicine, University Hospital, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Bosnic-Anticevich+SZ%22">Bosnic-Anticevich SZ</searchLink>; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia; Woolcock Institute of Medical Research, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bourdin+A%22">Bourdin A</searchLink>; PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Brusselle+GG%22">Brusselle GG</searchLink>; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Departments of Epidemiology and Respiratory Medicine, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Busby+J%22">Busby J</searchLink>; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Canonica+GW%22">Canonica GW</searchLink>; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Carter+V%22">Carter V</searchLink>; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chapman+KR%22">Chapman KR</searchLink>; University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Chapman+N%22">Chapman N</searchLink>; Saint Joseph Hospital, Denver, Colo; National Jewish Health, Denver, Colo.<br /><searchLink fieldCode="AU" term="%22Christoff+GC%22">Christoff GC</searchLink>; Bulgarian Alliance for Clinical and Translational Allergy, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Cosio+BG%22">Cosio BG</searchLink>; Son Espases University Hospital-IdISBa-Ciberes, Mallorca, Spain.<br /><searchLink fieldCode="AU" term="%22Costello+RW%22">Costello RW</searchLink>; Department of Respiratory Medicine, Clinical Research Centre, Smurfit Building Beaumont Hospital, RCSI, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Fingleton+J%22">Fingleton J</searchLink>; Capital and Coast District Health Board, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Fonseca+JA%22">Fonseca JA</searchLink>; CINTESIS@RISE (Center for Health Technology and Services Research at Health Research Network), MEDCIDS (Departamento Medicina da Comunidade, Informação e Decisão em Saúde/Department of Community Medicine, Information and Health Decisions), Faculty of Medicine of the University of Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Gaga+M%22">Gaga M</searchLink>; 1st Respiratory Medicine Department, Hygeia Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Gibson+PG%22">Gibson PG</searchLink>; Australian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, NSW, Australia; Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Hansen+S%22">Hansen S</searchLink>; Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Heaney+LG%22">Heaney LG</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Heffler+E%22">Heffler E</searchLink>; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Hew+M%22">Hew M</searchLink>; Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, VIC, Australia; Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Horiguchi+T%22">Horiguchi T</searchLink>; Toyota Regional Medical Center, Nishiyamacho, Toyota, Japan.<br /><searchLink fieldCode="AU" term="%22Hoyte+F%22">Hoyte F</searchLink>; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo.<br /><searchLink fieldCode="AU" term="%22Hubbard+RB%22">Hubbard RB</searchLink>; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom; Respiratory Medicine at the School of Medicine, University of Nottingham, Nottingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Iwanaga+T%22">Iwanaga T</searchLink>; Kindai University Hospital, Osakasayama, Japan.<br /><searchLink fieldCode="AU" term="%22Jackson+DJ%22">Jackson DJ</searchLink>; Guy's Severe Asthma Centre, School of Immunology & Microbial Sciences, King's College, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Katial+R%22">Katial R</searchLink>; Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, Colo.<br /><searchLink fieldCode="AU" term="%22Koh+MS%22">Koh MS</searchLink>; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Kostikas+K%22">Kostikas K</searchLink>; Respiratory Medicine Department, University of Ioannina, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Kuna+P%22">Kuna P</searchLink>; Division of Internal Medicine Asthma and Allergy, Medical University of Lodz, Lodz, Poland.<br /><searchLink fieldCode="AU" term="%22Lehmann+S%22">Lehmann S</searchLink>; Section of Thoracic Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Lehtimäki+L%22">Lehtimäki L</searchLink>; Allergy Centre, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Louis+R%22">Louis R</searchLink>; Department Pneumology CHU Liege, GIGA I(3) Research Group, University of Liege, Liege, Belgium.<br /><searchLink fieldCode="AU" term="%22Lúdvíksdóttir+D%22">Lúdvíksdóttir D</searchLink>; Department of Respiratory Medicine, Landspitali University Hospital Reykjavik Iceland, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Lugogo+N%22">Lugogo N</searchLink>; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Mich.<br /><searchLink fieldCode="AU" term="%22Mahboub+B%22">Mahboub B</searchLink>; Rashid Hospital, Dubai Health Authority (DHA), Dubai, United Arab Emirates; Dubai Academic and Health Corporation, Dubai, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Martin+N%22">Martin N</searchLink>; BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Md; Department of Respiratory Medicine, University of Leicester, Leicester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Máspero+J%22">Máspero J</searchLink>; Clinical Research for Allergy and Respiratory Medicine, CIDEA Foundation, Buenos Aires, Argentina; University Career of Specialists in Allergy and Clinical Immunology at the Buenos Aires University School of Medicine, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Menzies-Gow+AN%22">Menzies-Gow AN</searchLink>; Lung Division, Royal Brompton & Harefield Hospital, London, United Kingdom; AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mohan+A%22">Mohan A</searchLink>; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Mich.<br /><searchLink fieldCode="AU" term="%22Murray+RB%22">Murray RB</searchLink>; Optimum Patient Care Global, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Nagano+T%22">Nagano T</searchLink>; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Papadopoulos+NG%22">Papadopoulos NG</searchLink>; Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Papaioannou+AI%22">Papaioannou AI</searchLink>; 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Patel+PH%22">Patel PH</searchLink>; Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Perez-de-Llano+L%22">Perez-de-Llano L</searchLink>; Pneumology Service, Lucus Augusti University Hospital, EOXI Lugo, Monforte, Cervo, Spain.<br /><searchLink fieldCode="AU" term="%22Perng+DW%22">Perng DW</searchLink>; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Peters+MJ%22">Peters MJ</searchLink>; Department of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia; Faculty of Medicine, Health and Health Sciences, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Pfeffer+PE%22">Pfeffer PE</searchLink>; Department of Respiratory Medicine, Barts Health NHS Trust, London, United Kingdom; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pitrez+PM%22">Pitrez PM</searchLink>; Pulmonology Division, Hospital Santa Casa de Porto Alegre, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Pleasants+RA%22">Pleasants RA</searchLink>; Marsico Lung Institute, University of North Carolina, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Popov+TA%22">Popov TA</searchLink>; University Hospital St. Ivan Rilski, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Porsbjerg+CM%22">Porsbjerg CM</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Research Unit, Bispebjerg Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Puggioni+F%22">Puggioni F</searchLink>; Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Italy.<br /><searchLink fieldCode="AU" term="%22Quinton+A%22">Quinton A</searchLink>; AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rhee+CK%22">Rhee CK</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Sadatsafavi+M%22">Sadatsafavi M</searchLink>; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, the University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Salvi+S%22">Salvi S</searchLink>; Pulmocare Research and Education Foundation, Pune, India.<br /><searchLink fieldCode="AU" term="%22Scioscia+G%22">Scioscia G</searchLink>; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Sheu+CC%22">Sheu CC</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sirena+C%22">Sirena C</searchLink>; Severe Asthma Network Italy (SANI), Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Taillé+C%22">Taillé C</searchLink>; Department of Respiratory Diseases, Bichat Hospital, AP-HP, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Taube+C%22">Taube C</searchLink>; Department of Pulmonary Medicine, University Medical Center Essen-Ruhrlandklinik, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Torres-Duque+CA%22">Torres-Duque CA</searchLink>; CINEUMO, Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia; Universidad de La Sabana, Chia, Colombia.<br /><searchLink fieldCode="AU" term="%22Tsai+MJ%22">Tsai MJ</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tunsäter+A%22">Tunsäter A</searchLink>; Respiratory Medicine and Allergology, Department of Clinical Sciences, Skåne University Hospital, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Ulrik+CS%22">Ulrik CS</searchLink>; Department of Respiratory Medicine, Copenhagen University Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Price+DB%22">Price DB</searchLink>; Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address: dprice@opri.sg.
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      – Type: doi
        Value: 10.1016/j.jaip.2025.08.021
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      – Code: eng
        Text: English
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      – TitleFull: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach.
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              Text: 2025 Dec
              Type: published
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            – TitleFull: The journal of allergy and clinical immunology. In practice
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