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Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin.

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Title: Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin.
Authors: Stürzenberger S; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Bülow N; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Kalinichenko LS; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Erlangen, Germany., Licha R; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Erlangen, Germany., Eulenburg V; Translational Anesthesiology and Intensive Care, Universität Augsburg, Augsburg, Germany., Dahlmanns M; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Müller CP; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Erlangen, Germany.; Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Zheng F; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. fang.zheng@fau.de., Alzheimer C; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. christian.alzheimer@fau.de.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Feb; Vol. 31 (2), pp. 1027-1040. Date of Electronic Publication: 2025 Sep 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03210-x