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Green ultrasound‑assisted deep eutectic solvent extraction of flavonoid enzyme inhibitors from Blumea aromatica: process optimization, characterization, and mechanistic insights into α‑glucosidase and tyrosinase inhibition.

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Title: Green ultrasound‑assisted deep eutectic solvent extraction of flavonoid enzyme inhibitors from Blumea aromatica: process optimization, characterization, and mechanistic insights into α‑glucosidase and tyrosinase inhibition.
Authors: Dai W; Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, China.; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China., Dai L; College of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu, China.; Fogang County Maternal and Child Health Hospital, Fogang, China., Su T; College of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu, China.; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China., Lin Q; Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, China.; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China., Lin Z; Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, China.; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China., Ye S; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China., Xu P; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China., Chen H; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China., Zheng X; College of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu, China.
Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2552445. Date of Electronic Publication: 2025 Sep 04.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Dai+W%22">Dai W</searchLink>; Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, China.; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China.<br /><searchLink fieldCode="AU" term="%22Dai+L%22">Dai L</searchLink>; College of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu, China.; Fogang County Maternal and Child Health Hospital, Fogang, China.<br /><searchLink fieldCode="AU" term="%22Su+T%22">Su T</searchLink>; College of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu, China.; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Lin+Q%22">Lin Q</searchLink>; Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, China.; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China.<br /><searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink>; Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, China.; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China.<br /><searchLink fieldCode="AU" term="%22Ye+S%22">Ye S</searchLink>; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China.<br /><searchLink fieldCode="AU" term="%22Xu+P%22">Xu P</searchLink>; Comprehensive Experimental Teaching Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Yunfu, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+X%22">Zheng X</searchLink>; College of Traditional Chinese Medicine Resources, Guangdong Pharmaceutical University, Yunfu, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101150203 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-6374 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214756366%22">14756366 </searchLink><i>NLM ISO Abbreviation: </i>J Enzyme Inhib Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1080/14756366.2025.2552445
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        Text: English
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        StartPage: 2552445
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      – TitleFull: Green ultrasound‑assisted deep eutectic solvent extraction of flavonoid enzyme inhibitors from Blumea aromatica: process optimization, characterization, and mechanistic insights into α‑glucosidase and tyrosinase inhibition.
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              Text: 2025 Dec
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